Dissolution testing for prolonged-release solid dosage form containing drug substances degrading in test media. Application to polymeric delivery systems of paracetamol

A. A. Rakina, T. I. Spriridonova, S. I. Tverdokhlebov

Результат исследования: Материалы для журнала

Аннотация

Synthetic biodegradable polymers are widely used as materials for the targeted drug delivery and controlled release devices. In order to control the rate of drug release from polymer scaffolds surface ordinary dissolution testing is performed. It includes placing a device into testing media, taking probes at determined time and estimating the drug concentration. As for prolonged release the issue is the drug degradation in test media what leads to false interpretation of results. This study was focused on the investigation of paracetamol degradation in phosphate buffer saline media for three days and its effect on the results of polymeric drug delivery system dissolution test. It was shown, that relative error in the released drug concentration evaluation can rise up to 34% depending on the exposure time and the initial probe concentration. An approach of experimental results correction is proposed.

Язык оригиналаАнглийский
Артикульный номер12007
ЖурналIOP Conference Series: Materials Science and Engineering
Том511
Номер выпуска1
DOI
Статус публикацииОпубликовано - 24 апр 2019
СобытиеInternational Scientific and Technical Youth Conference on Perspective Materials of Constructional and Medical Purpose 2018, PMCP 2018 - Tomsk, Российская Федерация
Длительность: 26 ноя 201830 ноя 2018

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ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)

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