Differential pulse voltammetric determination of paracetamol in tablet and urine samples at a micro-crystalline natural graphite-polystyrene composite film modified electrode

Abdul Rauf Khaskheli, Jan Fischer, Jiří Barek, Vlastimil Vyskočil, Sirajuddin, Muhammad Iqbal Bhanger

Результат исследований: Материалы для журналаСтатья

52 Цитирования (Scopus)

Аннотация

A new extremely sensitive method for the determination of paracetamol by differential pulse voltammetry (DPV) using a micro-crystalline natural graphite-polystyrene composite film modified electrode (CFE) was developed. The experimental parameters, such as pH of Britton-Robinson buffer and potentials for regeneration of the electrode surface, were optimized. Under optimized conditions in Britton-Robinson buffer (pH 4.0), linear calibration curves were obtained in the range of 0.02-100 μmol l-1 of paracetamol. The limit of determination was 0.034 μmol l-1 which shows high sensitivity of the developed method. The method was applied for the determination of paracetamol in pharmaceutical formulations and in human urine model samples.

Язык оригиналаАнглийский
Страницы (с-по)238-242
Число страниц5
ЖурналElectrochimica Acta
Том101
DOI
СостояниеОпубликовано - 1 янв 2013
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Electrochemistry

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