Development and study of 99mTc-1-Thio-D-glucose for visualization of malignant tumors

R. Zeltchan, A. Medvedeva, I. Sinilkin, O. Bragina, V. Chernov, E. Stasyuk, A. Rogov, E. Il'Ina, V. Skuridin

Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

Аннотация

The preclinical studies of 99mTc-1-Thio-D-glucose, a new tumor-seeking agent based on technetium-99m-labeled glucose derivative, were conducted, and the feasibility of using this radiopharmaceutical for tumor visualization was studied. The preclinical studies were carried out strictly in accordance with the local legislation and were regulated by the generally accepted research standards. 99mTc-1-Thio-D-glucose was found to have optimal pharmacokinetic and physico-chemical properties for diagnostic imaging and was proved to belong to the low-toxic substances. The potential utility of 99mTc-1-thio-D-glucose for tumor imaging was studied in vitro and in vivo models. The present study demonstrated that 99mTc-1-Thio-D-glucose is a prospective radiopharmaceutical for cancer visualization.

Язык оригиналаАнглийский
Название основной публикацииPhysics of Cancer
Подзаголовок основной публикацииInterdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
РедакторыElazar Y. Gutmanas, Oleg B. Naimark, Yurii P. Sharkeev
ИздательAmerican Institute of Physics Inc.
ISBN (электронное издание)9780735415621
DOI
СостояниеОпубликовано - 28 сен 2017
СобытиеInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 - Tomsk, Российская Федерация
Продолжительность: 23 мая 201726 мая 2017

Серия публикаций

НазваниеAIP Conference Proceedings
Том1882
ISSN (печатное издание)0094-243X
ISSN (электронное издание)1551-7616

Конференция

КонференцияInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
СтранаРоссийская Федерация
ГородTomsk
Период23.5.1726.5.17

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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