Determination of the properties and loading efficiency of encapsulated BSA-FITC and dexamethasone for drug delivery systems

E. Chudinova, M. Surmeneva, A. Koptyug, V. Sokolova, O. Prymak, S. Bouckercha, M. Epple, R. Surmenev

Результат исследований: Материалы для журнала

Аннотация

In this work porous microparticles of calcium carbonate were synthesized with bovine serum albumin - fluorescein isothiocyanate conjugate (BSA-FITC) and dexamethasone, and then used for encapsulation in polymer microcapsules by means of layer-by-layer assembly (LbL). The properties of the obtained microcapsules were characterized by scanning electron microscopy, dynamic light scattering, infrared-, ultraviolet- and visible spectroscopy. According to the performed DLS measurements, an average hydrodynamic diameter ranged from 4 to 8 m and zeta-potential for all types of capsules was determined as -18 and -21 mV. BSA-FITC was encapsulated using this approach yielded a loading efficiency of 49 % protein. This value calculated for dexamethasone was of 38%. The microcapsules filled with an encapsulated drug may find applications in the field of biotechnology, biochemistry, and medicine.

Язык оригиналаАнглийский
Номер статьи012056
ЖурналIOP Conference Series: Materials Science and Engineering
Том597
Номер выпуска1
DOI
СостояниеОпубликовано - 23 авг 2019
Событие16th International Conference of Students and Young Scientists on Prospects of Fundamental Sciences Development, PFSD 2019 - Tomsk, Российская Федерация
Продолжительность: 23 апр 201926 апр 2019

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ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)

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