In this work porous microparticles of calcium carbonate were synthesized with bovine serum albumin - fluorescein isothiocyanate conjugate (BSA-FITC) and dexamethasone, and then used for encapsulation in polymer microcapsules by means of layer-by-layer assembly (LbL). The properties of the obtained microcapsules were characterized by scanning electron microscopy, dynamic light scattering, infrared-, ultraviolet- and visible spectroscopy. According to the performed DLS measurements, an average hydrodynamic diameter ranged from 4 to 8 m and zeta-potential for all types of capsules was determined as -18 and -21 mV. BSA-FITC was encapsulated using this approach yielded a loading efficiency of 49 % protein. This value calculated for dexamethasone was of 38%. The microcapsules filled with an encapsulated drug may find applications in the field of biotechnology, biochemistry, and medicine.
|Журнал||IOP Conference Series: Materials Science and Engineering|
|Состояние||Опубликовано - 23 авг 2019|
|Событие||16th International Conference of Students and Young Scientists on Prospects of Fundamental Sciences Development, PFSD 2019 - Tomsk, Российская Федерация|
Продолжительность: 23 апр 2019 → 26 апр 2019
ASJC Scopus subject areas
- Materials Science(all)