Design, synthesis and evaluation of a new Mn – Contrast agent for MR imaging of myocardium based on the DTPA-phenylpentadecanoic acid complex

Maxim L. Belyanin, Elena V. Stepanova, Rashid R. Valiev, Victor D. Filimonov, Vladimir Y. Usov, Oleg Y. Borodin, Hans Ågren

Результат исследований: Материалы для журналаСтатья

4 Цитирования (Scopus)

Аннотация

In the present paper we describe the first synthesis and evaluation of a novel Mn (II) complex (DTPA-PPDA Mn (II)) which contains a C-15 fatty acid moiety that has high affinity to the heart muscle. The complexation energy of DTPA-PPDA Mn (II) evaluated by quantum chemistry methodology indicates that it essentially exceeds the corresponding value for the known DTPA Mn (II) complex. Molecular docking revealed that the affinity of the designed complex to the heart-type transport protein H-FABP well exceeds that of lauric acid. Phantom experiments in low-field MRI the designed contrast agent provides MR imaging comparable to gadopentetic acid.

Язык оригиналаАнглийский
Страницы (с-по)111-116
Число страниц6
ЖурналChemical Physics Letters
Том665
DOI
СостояниеОпубликовано - 16 ноя 2016

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

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