Decomposition of reactive oxygen species by copper(II) bis(1-pyrazolyl) methane complexes

Igor Schepetkin, Andrei Sergeevich Potapov, Andrey Ivanovich Khlebnikov, Elena Korotkova, Anna Lukina, Galina Malovichko, Lilia Kirpotina, Mark T. Quinn

Результат исследований: Материалы для журналаСтатьярецензирование

66 Цитирования (Scopus)

Аннотация

Two bis(1-pyrazolyl)alkane ligands, bis(3,5-dimethyl-1-pyrazolyl)methane and bis(4-iodo-3,5-dimethyl-1-pyrazolyl)methane, and their copper(II) complexes, bis(3,5-dimethyl-1-pyrazolyl)methanedinitratocopper(II) [CuL 1(NO3)2] and bis(4-iodo-3,5-dimethyl-1- pyrazolyl)methanedinitratocopper(II) [CuL2(NO3) 2]•2H2O, were prepared. Physiochemical properties of the copper(II) complexes were studied by spectroscopic (UV-vis, IR, EPR) techniques and cyclic voltammetry. Spectroscopic analysis revealed a 1:1 stoichiometry of ligand:copper(II) ion and a bindentate coordination mode for the nitrate ions in both of the complexes. According to experimental and theoretical ab initio data, the copper(II) ion is located in an octahedral hexacoordinated environment. Both complexes were able to catalyze the dismutation of superoxide anion ( $$ {\text{O}}^{{\bullet - }}_{{\text{2}}} $$ ) (pH 7.5) and decomposition of H 2O2 (pH 7.5) and peroxynitrite (pH 10.9). In addition, both complexes exhibited superoxide dismutase (SOD) like activity toward extracellular and intracellular reactive oxygen species produced by activated human neutrophils in whole blood. Thus, these complexes represent useful SOD mimetics with a broad range of antioxidant activity toward a variety of reactive oxidants.

Язык оригиналаАнглийский
Страницы (с-по)499-513
Число страниц15
ЖурналJournal of Biological Inorganic Chemistry
Том11
Номер выпуска4
DOI
СостояниеОпубликовано - 1 июн 2006

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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