CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects

S. A. Ivanova, M. L. Filipenko, N. M. Vyalova, E. N. Voronina, I. V. Pozhidaev, D. Z. Osmanova, M. V. Ivanov, O. Y. Fedorenko, A. V. Semke, N. A. Bokhan

Результат исследований: Материалы для журналаСтатья

7 Цитирования (Scopus)

Аннотация

Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.

Язык оригиналаАнглийский
Страницы (с-по)1-4
Число страниц4
ЖурналBulletin of Experimental Biology and Medicine
DOI
СостояниеПринято/в печати - 29 мар 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Подробные сведения о темах исследования «CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects». Вместе они формируют уникальный семантический отпечаток (fingerprint).

  • Цитировать

    Ivanova, S. A., Filipenko, M. L., Vyalova, N. M., Voronina, E. N., Pozhidaev, I. V., Osmanova, D. Z., Ivanov, M. V., Fedorenko, O. Y., Semke, A. V., & Bokhan, N. A. (Принято в печать). CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects. Bulletin of Experimental Biology and Medicine, 1-4. https://doi.org/10.1007/s10517-016-3250-4