Current outlook on radionuclide delivery systems: From design consideration to translation into clinics

Oleksii O. Peltek, Albert R. Muslimov, Mikhail V. Zyuzin, Alexander S. Timin

Результат исследований: Материалы для журналаОбзорная статья

2 Цитирования (Scopus)

Аннотация

Radiopharmaceuticals have proven to be effective agents, since they can be successfully applied for both diagnostics and therapy. Effective application of relevant radionuclides in pre-clinical and clinical studies depends on the choice of a sufficient delivery platform. Herein, we provide a comprehensive review on the most relevant aspects in radionuclide delivery using the most employed carrier systems, including, (i) monoclonal antibodies and their fragments, (ii) organic and (iii) inorganic nanoparticles, and (iv) microspheres. This review offers an extensive analysis of radionuclide delivery systems, the approaches of their modification and radiolabeling strategies with the further prospects of their implementation in multimodal imaging and disease curing. Finally, the comparative outlook on the carriers and radionuclide choice, as well as on the targeting efficiency of the developed systems is discussed.

Язык оригиналаАнглийский
Номер статьи90
ЖурналJournal of Nanobiotechnology
Том17
Номер выпуска1
DOI
СостояниеОпубликовано - 21 авг 2019

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Applied Microbiology and Biotechnology
  • Pharmaceutical Science

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