Cryotherapy in inflammatory rheumatic diseases: A systematic review

Xavier Guillot, Nicolas Tordi, Laurent Mourot, Céline Demougeot, Benoît Dugué, Clément Prati, Daniel Wendling

Результат исследований: Материалы для журналаОбзорная статья

55 Цитирования (Scopus)

Аннотация

The aim of this article was to review current evidence about cryotherapy in inflammatory rheumatic diseases (therapeutic and biological effects). For therapeutic effects, we performed a systematic review (PubMed, EMBASE, Cochrane Library, LILACS databases, unpublished data) and selected studies including non-operated and non-infected arthritic patients treated with local cryotherapy or whole-body cryotherapy. By pooling 6 studies including 257 rheumatoid arthritis (RA) patients, we showed a significant decrease in pain visual analogic scale (mm) and 28-joint disease activity score after chronic cryotherapy in RA patients. For molecular pathways, local cryotherapy induces an intrajoint temperature decrease, which might downregulate several mediators involved in joint inflammation and destruction (cytokines, cartilage-degrading enzymes, proangiogenic factors), but studies in RA are rare. Cryotherapy should be included in RA therapeutic strategies as an adjunct therapy, with potential corticosteroid and nonsteroidal anti-inflammatory drug dose-sparing effects. However, techniques and protocols should be more precisely defined in randomized controlled trials with stronger methodology.

Язык оригиналаАнглийский
Страницы (с-по)281-294
Число страниц14
ЖурналExpert Review of Clinical Immunology
Том10
Номер выпуска2
DOI
СостояниеОпубликовано - 1 фев 2014
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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