Conformational stability of leukocyte lactate dehydrogenase in healthy men of different age

O. Yu Fedorenko, N. A. Bokhan, S. A. Ivanova

Результат исследований: Материалы для журналаСтатья

1 цитирование (Scopus)

Выдержка

Comparative analysis of cytosolic fraction distribution and conformational stability in lactate dehydrogenase (LDH) isozymes in healthy men of different age revealed significant differences indicating age-related characteristics of the enzyme. Activity of cytosolic fraction of LDH-1 and conformational stability of LDH-2 and LDH-3 in 40-year-old men were higher than in 20-year-olds. These data suggest age-related determination of conformational stability of individual LDH isozymes and functional heterogeneity of the enzyme within each isoform.

Язык оригиналаАнглийский
Страницы (с-по)44-46
Число страниц3
ЖурналBulletin of Experimental Biology and Medicine
Том154
Номер выпуска1
DOI
СостояниеОпубликовано - ноя 2012

Отпечаток

L-Lactate Dehydrogenase
Isoenzymes
Leukocytes
Enzymes
Protein Isoforms
lactate dehydrogenase 2
lactate dehydrogenase 1
lactate dehydrogenase 3

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Цитировать

Conformational stability of leukocyte lactate dehydrogenase in healthy men of different age. / Fedorenko, O. Yu; Bokhan, N. A.; Ivanova, S. A.

В: Bulletin of Experimental Biology and Medicine, Том 154, № 1, 11.2012, стр. 44-46.

Результат исследований: Материалы для журналаСтатья

@article{01053a5cf4d9442a96c5b12663b5a6d5,
title = "Conformational stability of leukocyte lactate dehydrogenase in healthy men of different age",
abstract = "Comparative analysis of cytosolic fraction distribution and conformational stability in lactate dehydrogenase (LDH) isozymes in healthy men of different age revealed significant differences indicating age-related characteristics of the enzyme. Activity of cytosolic fraction of LDH-1 and conformational stability of LDH-2 and LDH-3 in 40-year-old men were higher than in 20-year-olds. These data suggest age-related determination of conformational stability of individual LDH isozymes and functional heterogeneity of the enzyme within each isoform.",
keywords = "age features, conformational stability, lactate dehydrogenase, leukocytes",
author = "Fedorenko, {O. Yu} and Bokhan, {N. A.} and Ivanova, {S. A.}",
year = "2012",
month = "11",
doi = "10.1007/s10517-012-1871-9",
language = "English",
volume = "154",
pages = "44--46",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Conformational stability of leukocyte lactate dehydrogenase in healthy men of different age

AU - Fedorenko, O. Yu

AU - Bokhan, N. A.

AU - Ivanova, S. A.

PY - 2012/11

Y1 - 2012/11

N2 - Comparative analysis of cytosolic fraction distribution and conformational stability in lactate dehydrogenase (LDH) isozymes in healthy men of different age revealed significant differences indicating age-related characteristics of the enzyme. Activity of cytosolic fraction of LDH-1 and conformational stability of LDH-2 and LDH-3 in 40-year-old men were higher than in 20-year-olds. These data suggest age-related determination of conformational stability of individual LDH isozymes and functional heterogeneity of the enzyme within each isoform.

AB - Comparative analysis of cytosolic fraction distribution and conformational stability in lactate dehydrogenase (LDH) isozymes in healthy men of different age revealed significant differences indicating age-related characteristics of the enzyme. Activity of cytosolic fraction of LDH-1 and conformational stability of LDH-2 and LDH-3 in 40-year-old men were higher than in 20-year-olds. These data suggest age-related determination of conformational stability of individual LDH isozymes and functional heterogeneity of the enzyme within each isoform.

KW - age features

KW - conformational stability

KW - lactate dehydrogenase

KW - leukocytes

UR - http://www.scopus.com/inward/record.url?scp=84877149604&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877149604&partnerID=8YFLogxK

U2 - 10.1007/s10517-012-1871-9

DO - 10.1007/s10517-012-1871-9

M3 - Article

C2 - 23330087

AN - SCOPUS:84877149604

VL - 154

SP - 44

EP - 46

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 1

ER -