Comparing the measured affinity of 111In-labeled ligands for cellular receptors by monitoring gamma, beta, or X-ray radiation with three different LigandTracer® devices

Zohreh Varasteh, Anna Orlova

Результат исследований: Материалы для журналаСтатьярецензирование

4 Цитирования (Scopus)

Аннотация

LigandTracer instruments measuring high energy photons (gamma-rays), particles (electrons and positrons) and low energy photons (X-rays) are novel semi-automated devices which produce real-time radiotracer-receptor interaction data for measurement of the affinity. The affinities of two different 111In-labeled ligands were measured in three different LigandTracer devices detecting high energy gamma, Auger and internal conversion electrons, or X-rays. The obtained similar uptake/retention patterns (binding curves) show that even at low signal-to-noise ratios (data from Auger and internal conversion electrons, and X-rays), reliable binding data can be captured. This verifies that different devices could be used as alternatives for kinetic evaluation studies for radionuclides emitting different type of radiation.

Язык оригиналаАнглийский
Страницы (с-по)823-828
Число страниц6
ЖурналJournal of Radioanalytical and Nuclear Chemistry
Том304
Номер выпуска2
DOI
СостояниеОпубликовано - 1 мая 2015
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Fingerprint Подробные сведения о темах исследования «Comparing the measured affinity of <sup>111</sup>In-labeled ligands for cellular receptors by monitoring gamma, beta, or X-ray radiation with three different LigandTracer<sup>®</sup> devices». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать