Comparative Study of the Physical, Topographical and Biological Properties of Electrospinning PCL, PLLA, their Blend and Copolymer Scaffolds

E. Bolbasov, S. Goreninskii, S. Tverdokhlebov, A. Mishanin, A. Viknianshchuk, D. Bezuidenhout, A. Golovkin

Результат исследований: Материалы для журнала

4 Цитирования (Scopus)

Аннотация

Biodegradable polymers (blends, copolymers) could be the ideal materials for manufacturing of scaffolds for small diameter vascular graft. Such material characteristics as mechanical properties, chemical structure, nano- and micro topography, surface charge, porosity, wettability etc. are becoming the most important aspects for effectiveness of prosthesis biofunctionalization because of their great impact on cell adhesion, spreading, cell proliferation, differentiation and cell function. The aim of the study is to compare physical, topographical and biological properties of polycaprolactone (PCL), poly-L-lactic acid (PLLA), polycaprolactone + poly-L-lactic acid blend (PCL PLLA), L-lactide/Caprolactone copolymer (PLC7015) scaffolds fabricated with the same fiber thickness using electrospun technology. PCL PLLA scaffolds had the highest average pore area (p<0.01) and the lowest strength (p<0.01). PLC7015 scaffolds had the significantly lower average pore area (p=0.03) but the highest elastic deformation (p<0.01). Biological testing with MMSC (multipotent mesenchyme stem cells) demonstrated that after 72 hours of co-cultivation only on PCL and PLLA scaffolds cells entered to the active phase of adhesion process. We propose that physical and topographical properties of PCL, PLLA, their blend and copolymer are of a great dependence of chemical structure but could be changed during the manufacturing process that will lead to changes in biological properties.

Язык оригиналаАнглийский
Номер статьи012012
ЖурналIOP Conference Series: Materials Science and Engineering
Том350
Номер выпуска1
DOI
СостояниеОпубликовано - 14 мая 2018
Событие2017 International Conference on Nanomaterials and Biomaterials, ICNB 2017 - Amsterdam, Нидерланды
Продолжительность: 11 дек 201713 дек 2017

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)

Цитировать