Cognitive functions and a BDNF gene polymorphism in schizophrenia patients and healthy individuals

Anastasiia Boiko, Ekaterina Mikhalitskaya, Elena Kornetova, Svetlana Ivanova

Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

Аннотация

In a number of schizophrenia concepts, the neurocognitive deficiency is distinguished to a separate domain along with positive and negative disorders, and it is an important predictor of the unfavourable prognosis of the course of the disease and the development of persistent social dysfunction. The contribution of genetic mechanisms has been proven in the variability of attention instability and long-term memory impairment. Brain derived neurotrophic factor (BDNF) regulates a number of aspects of cell differentiation and survival; it is also required in synaptic plasticity and long-term potentiation (that determine learning and memory). In this study, we compared cognitive functions in schizophrenia cases and healthy controls. We also evaluated associations between cognitive functions and a BDNF gene polymorphism. It was a complex evaluation of 550 schizophrenia patients and 485 healthy persons. The BDNF polymorphism rs6265 was not associated with schizophrenia. Cognitive functions were evaluated in 160 schizophrenia cases and 106 healthy controls using the BACS scale. The indicators of cognitive function in schizophrenia cases were significantly worse in comparison with healthy subjects. Associations of genotypes of polymorphism rs6265 of the BDNF gene were detected with performing subtests of the BACS scale.

Язык оригиналаАнглийский
Название основной публикацииProceedings - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020
ИздательInstitute of Electrical and Electronics Engineers Inc.
Страницы65-67
Число страниц3
ISBN (электронное издание)9781728195971
DOI
СостояниеОпубликовано - июл 2020
Опубликовано для внешнего пользованияДа
Событие2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020 - Novosibirsk, Российская Федерация
Продолжительность: 6 июл 202010 июл 2020

Серия публикаций

НазваниеProceedings - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020

Конференция

Конференция2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020
СтранаРоссийская Федерация
ГородNovosibirsk
Период6.7.2010.7.20

ASJC Scopus subject areas

  • Information Systems
  • Decision Sciences (miscellaneous)
  • Cognitive Neuroscience
  • Health Informatics
  • Genetics
  • Artificial Intelligence
  • Computer Science Applications

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