Clinical experience of the use of autologous mononuclear bone marrow cells in patients with ischemic heart disease and dilated cardiomyopathy

Sh D. Akhmedov, V. E. Babokin, V. V. Ryabov, T. E. Suslova, V. I. Chernov, S. I. Sazonova, Yu V. Rogovskaya, Yu G. Korkin, A. P. Motreva, V. M. Shipulin, R. S. Karpov

Результат исследований: Материалы для журнала › Статья › рецензирование

1 Цитирования (Scopus)

Аннотация

Between March 2003 and February 2005 cell therapy with mononuclear bone marrow cells (MBMC) was used in 38 and 4 patients with ischemic heart disease and dilated cardiomyopathy, respectively. Intracardiac administration of MBMC (87±12 millions) was carried out during coronary artery bypass surgery and/or left ventricular aneurism resection (n=25) or in cardiac catheterization laboratory (n=17). For verification of cells fixation they were labeled with "Ceretec" ^99mTc-HMPAO. Accumulation of labeled cells after 24 hours was 1.6±0.001%. After 6 months parameters of intracardiac hemodynamics and transitory myocardial perfusion defects improved significantly in all patients with ischemic heart disease.

Язык оригинала	Английский
Страницы (с-по)	10-14
Число страниц	5
Журнал	Kardiologiya
Том	46
Номер выпуска	7
Состояние	Опубликовано - 2006
Опубликовано для внешнего пользования	Да

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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Clinical experience of the use of autologous mononuclear bone marrow cells in patients with ischemic heart disease and dilated cardiomyopathy. / Akhmedov, Sh D.; Babokin, V. E.; Ryabov, V. V.; Suslova, T. E.; Chernov, V. I.; Sazonova, S. I.; Rogovskaya, Yu V.; Korkin, Yu G.; Motreva, A. P.; Shipulin, V. M.; Karpov, R. S.

В: Kardiologiya, Том 46, № 7, 2006, стр. 10-14.

Результат исследований: Материалы для журнала › Статья › рецензирование

Akhmedov, Sh D. ; Babokin, V. E. ; Ryabov, V. V. ; Suslova, T. E. ; Chernov, V. I. ; Sazonova, S. I. ; Rogovskaya, Yu V. ; Korkin, Yu G. ; Motreva, A. P. ; Shipulin, V. M. ; Karpov, R. S. / Clinical experience of the use of autologous mononuclear bone marrow cells in patients with ischemic heart disease and dilated cardiomyopathy. В: Kardiologiya. 2006 ; Том 46, № 7. стр. 10-14.

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author = "Akhmedov, {Sh D.} and Babokin, {V. E.} and Ryabov, {V. V.} and Suslova, {T. E.} and Chernov, {V. I.} and Sazonova, {S. I.} and Rogovskaya, {Yu V.} and Korkin, {Yu G.} and Motreva, {A. P.} and Shipulin, {V. M.} and Karpov, {R. S.}",

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T1 - Clinical experience of the use of autologous mononuclear bone marrow cells in patients with ischemic heart disease and dilated cardiomyopathy

AU - Akhmedov, Sh D.

AU - Babokin, V. E.

AU - Ryabov, V. V.

AU - Suslova, T. E.

AU - Chernov, V. I.

AU - Sazonova, S. I.

AU - Rogovskaya, Yu V.

AU - Korkin, Yu G.

AU - Motreva, A. P.

AU - Shipulin, V. M.

AU - Karpov, R. S.

PY - 2006

Y1 - 2006

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AB - Between March 2003 and February 2005 cell therapy with mononuclear bone marrow cells (MBMC) was used in 38 and 4 patients with ischemic heart disease and dilated cardiomyopathy, respectively. Intracardiac administration of MBMC (87±12 millions) was carried out during coronary artery bypass surgery and/or left ventricular aneurism resection (n=25) or in cardiac catheterization laboratory (n=17). For verification of cells fixation they were labeled with "Ceretec" 99mTc-HMPAO. Accumulation of labeled cells after 24 hours was 1.6±0.001%. After 6 months parameters of intracardiac hemodynamics and transitory myocardial perfusion defects improved significantly in all patients with ischemic heart disease.

KW - Cell therapy

KW - Cellular cardiomyoplasty

KW - Heart failure, treatment

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