Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Gulmira Özek, Igor A. Schepetkin, Gulzhakhan A. Utegenova, Liliya N. Kirpotina, Spencer R. Andrei, Temel Özek, Kemal Hüsnü Can Başer, Karime T. Abidkulova, Svetlana V. Kushnarenko, Andrei I. Khlebnikov, Derek S. Damron, Mark T. Quinn

Результат исследований: Материалы для журналаСтатья

4 Цитирования (Scopus)

Выдержка

Essential oil extracts from Ferula iliensis have been used traditionally in Kazakhstan for treatment of inflammation and other illnesses. Because little is known about the biologic activity of these essential oils that contributes to their therapeutic properties, we analyzed their chemical composition and evaluated their phagocyte immunomodulatory activity. The main components of the extracted essential oils were (E)-propenyl sec-butyl disulfide (15.7-39.4%) and (Z)-propenyl sec-butyl disulfide (23.4-45.0%). Ferula essential oils stimulated [Ca2+]i mobilization in human neutrophils and activated ROS production in human neutrophils and murine bone marrow phagocytes. Activation of human neutrophil [Ca2+]i flux by Ferula essential oils was dose-dependently inhibited by capsazepine, a TRPV1 channel antagonist, indicating that TRPV1 channels mediate this response. Furthermore, Ferula essential oils stimulated Ca2+ influx in TRPV1 channel-transfected HEK293 cells and desensitized the capsaicin-induced response in these cells. Additional molecular modeling with known TRPV1 channel agonists suggested that the active component is likely to be (Z)-propenyl sec-butyl disulfide. Our results provide a cellular and molecular basis to explain at least part of the beneficial therapeutic properties of FEOs.

Язык оригиналаАнглийский
Страницы (с-по)1361-1371
Число страниц11
ЖурналJournal of Leukocyte Biology
Том101
Номер выпуска6
DOI
СостояниеОпубликовано - 1 июн 2017

Отпечаток

Ferula
Volatile Oils
Phagocytes
Disulfides
Neutrophils
Kazakhstan
Neutrophil Activation
HEK293 Cells
Capsaicin
Bone Marrow
Inflammation
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Цитировать

Özek, G., Schepetkin, I. A., Utegenova, G. A., Kirpotina, L. N., Andrei, S. R., Özek, T., ... Quinn, M. T. (2017). Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils. Journal of Leukocyte Biology, 101(6), 1361-1371. https://doi.org/10.1189/jlb.3A1216-518RR

Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils. / Özek, Gulmira; Schepetkin, Igor A.; Utegenova, Gulzhakhan A.; Kirpotina, Liliya N.; Andrei, Spencer R.; Özek, Temel; Başer, Kemal Hüsnü Can; Abidkulova, Karime T.; Kushnarenko, Svetlana V.; Khlebnikov, Andrei I.; Damron, Derek S.; Quinn, Mark T.

В: Journal of Leukocyte Biology, Том 101, № 6, 01.06.2017, стр. 1361-1371.

Результат исследований: Материалы для журналаСтатья

Özek, G, Schepetkin, IA, Utegenova, GA, Kirpotina, LN, Andrei, SR, Özek, T, Başer, KHC, Abidkulova, KT, Kushnarenko, SV, Khlebnikov, AI, Damron, DS & Quinn, MT 2017, 'Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils', Journal of Leukocyte Biology, том. 101, № 6, стр. 1361-1371. https://doi.org/10.1189/jlb.3A1216-518RR
Özek, Gulmira ; Schepetkin, Igor A. ; Utegenova, Gulzhakhan A. ; Kirpotina, Liliya N. ; Andrei, Spencer R. ; Özek, Temel ; Başer, Kemal Hüsnü Can ; Abidkulova, Karime T. ; Kushnarenko, Svetlana V. ; Khlebnikov, Andrei I. ; Damron, Derek S. ; Quinn, Mark T. / Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils. В: Journal of Leukocyte Biology. 2017 ; Том 101, № 6. стр. 1361-1371.
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AU - Andrei, Spencer R.

AU - Özek, Temel

AU - Başer, Kemal Hüsnü Can

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AU - Kushnarenko, Svetlana V.

AU - Khlebnikov, Andrei I.

AU - Damron, Derek S.

AU - Quinn, Mark T.

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