Cation-chloride cotransporters: Regulation, physiological significance, and role in pathogenesis of arterial hypertension

S. N. Orlov, S. V. Koltsova, L. V. Kapilevich, N. O. Dulin, S. V. Gusakova

Результат исследований: Материалы для журналаОбзорная статья

5 Цитирования (Scopus)

Аннотация

This review summarizes the data on the functioning of carriers providing electroneutral symport of sodium, potassium, and chloride (Na+,K+,2Cl- cotransport), potassium and chloride (K+,Cl- cotransport), and sodium and chloride (K+,Cl- cotransport) as well as molecular mechanisms of the regulation of these carriers and their physiological significance. We emphasized the involvement of chloride-coupled carriers in the regulation of cell volume and intracellular chloride concentration and novel data on the role of ubiquitous isoform of Na+,K+,2Cl- cotransporter NKCC1 in regulation of vascular smooth muscle contraction and activity of GABAA receptors. Finally, we analyzed the data on activation of NKCC1 in patients with essential hypertension and its role in the long-term maintenance of elevated systemic blood pressure and myogenic response in microcirculatory beds.

Язык оригиналаАнглийский
Страницы (с-по)1546-1561
Число страниц16
ЖурналBiochemistry (Moscow)
Том79
Номер выпуска13
DOI
СостояниеОпубликовано - 2014
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)

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