Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation

L. N. Maslov, Yu B. Lishmanov, E. I. Barzakh, I. V. Maksimov, I. N. Vorozhtsova, I. L. Bukhovets, S. M. Minin, E. B. Orlova, A. G. Lavrov, M. V. Ovchinnlkov

Результат исследований: Материалы для журналаСтатья

1 цитирование (Scopus)

Выдержка

It has been established that intravenous administration of dalargin at a dose of 0.1 mg/kg induced hypotensive, positive inotropic, and positive chronotropic response in patients with myocardial infarction, while not producing the "steal syndrome." The positive chronotropic effect of dalargin was mediated by peripheral μ-opioid receptors. Increase in the heart rate induced by dalargin had a reflex nature. Direct action of dalargin on the heart was accompanied by a decrease in the heart rate and a delay in the cardiac conductance in the atrioventricular junction region.

Язык оригиналаАнглийский
Страницы (с-по)21-28
Число страниц8
ЖурналEksperimental'naya i Klinicheskaya Farmakologiya
Том71
Номер выпуска2
СостояниеОпубликовано - 2008

Отпечаток

Opioid Receptors
Heart Rate
Chemical activation
Intravenous Administration
Reflex
Myocardial Infarction

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Цитировать

Maslov, L. N., Lishmanov, Y. B., Barzakh, E. I., Maksimov, I. V., Vorozhtsova, I. N., Bukhovets, I. L., ... Ovchinnlkov, M. V. (2008). Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation. Eksperimental'naya i Klinicheskaya Farmakologiya, 71(2), 21-28.

Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation. / Maslov, L. N.; Lishmanov, Yu B.; Barzakh, E. I.; Maksimov, I. V.; Vorozhtsova, I. N.; Bukhovets, I. L.; Minin, S. M.; Orlova, E. B.; Lavrov, A. G.; Ovchinnlkov, M. V.

В: Eksperimental'naya i Klinicheskaya Farmakologiya, Том 71, № 2, 2008, стр. 21-28.

Результат исследований: Материалы для журналаСтатья

Maslov, LN, Lishmanov, YB, Barzakh, EI, Maksimov, IV, Vorozhtsova, IN, Bukhovets, IL, Minin, SM, Orlova, EB, Lavrov, AG & Ovchinnlkov, MV 2008, 'Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation', Eksperimental'naya i Klinicheskaya Farmakologiya, том. 71, № 2, стр. 21-28.
Maslov, L. N. ; Lishmanov, Yu B. ; Barzakh, E. I. ; Maksimov, I. V. ; Vorozhtsova, I. N. ; Bukhovets, I. L. ; Minin, S. M. ; Orlova, E. B. ; Lavrov, A. G. ; Ovchinnlkov, M. V. / Cardiovascular effects of D-ALA, LEU, ARG-ENKEPHALIN (dalargin) are mediated by peripheral μ-opioid receptor activation. В: Eksperimental'naya i Klinicheskaya Farmakologiya. 2008 ; Том 71, № 2. стр. 21-28.
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abstract = "It has been established that intravenous administration of dalargin at a dose of 0.1 mg/kg induced hypotensive, positive inotropic, and positive chronotropic response in patients with myocardial infarction, while not producing the {"}steal syndrome.{"} The positive chronotropic effect of dalargin was mediated by peripheral μ-opioid receptors. Increase in the heart rate induced by dalargin had a reflex nature. Direct action of dalargin on the heart was accompanied by a decrease in the heart rate and a delay in the cardiac conductance in the atrioventricular junction region.",
author = "Maslov, {L. N.} and Lishmanov, {Yu B.} and Barzakh, {E. I.} and Maksimov, {I. V.} and Vorozhtsova, {I. N.} and Bukhovets, {I. L.} and Minin, {S. M.} and Orlova, {E. B.} and Lavrov, {A. G.} and Ovchinnlkov, {M. V.}",
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AU - Maslov, L. N.

AU - Lishmanov, Yu B.

AU - Barzakh, E. I.

AU - Maksimov, I. V.

AU - Vorozhtsova, I. N.

AU - Bukhovets, I. L.

AU - Minin, S. M.

AU - Orlova, E. B.

AU - Lavrov, A. G.

AU - Ovchinnlkov, M. V.

PY - 2008

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