Cardioprotective effects of stimulation of peripheral μ-opiate receptors and the role of opiatergic mechanisms in the pathogenesis of stress-induced heart damage

Yu B. Lishmanov, L. N. Maslov, N. V. Naryzhnaya

Результат исследования: Материалы для журналаСтатья

1 Цитирования (Scopus)

Аннотация

Immobilization induces stress damage to the heart. DAGO, an agonist of μ-opiate receptors potentiates, while an agonist of peripheral μ-opiate receptors prevents this damage. Naltrexone reduces, while methylnaltrexone, an inhibitor of peripheral μ-opiate receptors, potentiates the stress-induced damage to the heart. Other opiate ligands have no effect on heart damage. It is suggested that the stress-induced damage to the heart is promoted by activation of central μ-opiate receptors and prevented by stimulation of peripheral μ-opiate receptors.

Язык оригиналаАнглийский
Страницы (с... по...)239-241
Количество страниц3
ЖурналBulletin of Experimental Biology and Medicine
Том123
Номер выпуска3
DOI
Статус публикацииОпубликовано - мар 1997

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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