Botanical polysaccharides: Macrophage immunomodulation and therapeutic potential

Igor A. Schepetkin, Mark T. Quinn

Результат исследований: Материалы для журналаОбзорная статья

754 Цитирования (Scopus)

Выдержка

Botanical polysaccharides exhibit a number of beneficial therapeutic properties, and it is thought that the mechanisms involved in these effects are due to the modulation of innate immunity and, more specifically, macrophage function. In this review, we summarize our current state of understanding of the macrophage modulatory effects of botanical polysaccharides isolated from a wide array of different species of flora, including higher plants, mushrooms, lichens and algae. Overall, the primary effect of botanical polysaccharides is to enhance and/or activate macrophage immune responses, leading to immunomodulation, anti-tumor activity, wound-healing and other therapeutic effects. Furthermore, botanical and microbial polysaccharides bind to common surface receptors and induce similar immunomodulatory responses in macrophages, suggesting that evolutionarily conserved polysaccharide structural features are shared between these organisms. Thus, the evaluation of botanical polysaccharides provides a unique opportunity for the discovery of novel therapeutic agents and adjuvants that exhibit beneficial immunomodulatory properties.

Язык оригиналаАнглийский
Страницы (с-по)317-333
Число страниц17
ЖурналInternational Immunopharmacology
Том6
Номер выпуска3
DOI
СостояниеОпубликовано - мар 2006
Опубликовано для внешнего пользованияДа

Отпечаток

Immunomodulation
Polysaccharides
Macrophages
Therapeutics
Lichens
Agaricales
Therapeutic Uses
Innate Immunity
Wound Healing
Neoplasms

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Цитировать

Botanical polysaccharides : Macrophage immunomodulation and therapeutic potential. / Schepetkin, Igor A.; Quinn, Mark T.

В: International Immunopharmacology, Том 6, № 3, 03.2006, стр. 317-333.

Результат исследований: Материалы для журналаОбзорная статья

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