Blood-Derived RNA- and microRNA-Hydrolyzing IgG Antibodies in Schizophrenia Patients

E. A. Ermakov, S. A. Ivanova, V. N. Buneva, G. A. Nevinsky

Результат исследований: Материалы для журналаСтатьярецензирование

6 Цитирования (Scopus)

Аннотация

Abzymes with various catalytic activities are the earliest statistically significant markers of existing and developing autoimmune diseases (AIDs). Currently, schizophrenia (SCZD) is not considered to be a typical AID. It was demonstrated recently that antibodies from SCZD patients efficiently hydrolyze DNA and myelin basic protein. Here, we showed for the first time that autoantibodies from 35 SCZD patients efficiently hydrolyze RNA (cCMP > poly(C) > poly(A) > yeast RNA) and analyzed site-specific hydrolysis of microRNAs involved in the regulation of several genes in SCZD (miR-137, miR-9-5p, miR-219-2-3p, and miR-219a-5p). All four microRNAs were cleaved by IgG preparations (n = 21) from SCZD patients in a site-specific manner. The RNase activity of the abzymes correlated with SCZD clinical parameters. The data obtained showed that SCZD patients might display signs of typical autoimmune processes associated with impaired functioning of microRNAs resulting from their hydrolysis by the abzymes.

Язык оригиналаАнглийский
Страницы (с-по)507-526
Число страниц20
ЖурналBiochemistry (Moscow)
Том83
Номер выпуска5
DOI
СостояниеОпубликовано - 1 мая 2018
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Biochemistry

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