Выдержка
Superparamagnetic particles of Fe3 O4 in ferrofluid were injected transcranially in the ventricle of the rat brain. At three months after the injection the rat was sacrificed and the brain was investigated by Mössbauer spectroscopy and histological Perls Prussian blue method. Histological examination demonstrated increased concentration of blue areas in parenchyma and on the dura mater of the brain of experimental rat in comparison with the brain of control rat, indicating appearance in the brain of some undegradable compound of iron. Mössbauer spectra showed the presence in the ferrofluid of both Fe3 O4 nanoparticles and an additional chemical compound which contains ferric iron in the high-spin state. Comparison of the Mössbauer spectra of the ferrofluid, of the brain before injection and of the brain three months after injection shows that the Fe3 O4 nanoparticles were removed from the brain in three months. At the same time this additional chemical compound does not decompose and remains in the brain intact.
| Язык оригинала | Английский |
|---|---|
| Номер статьи | 6392406 |
| Страницы (с-по) | 436-439 |
| Число страниц | 4 |
| Журнал | IEEE Transactions on Magnetics |
| Том | 49 |
| Номер выпуска | 1 |
| DOI | |
| Состояние | Опубликовано - 2013 |
| Опубликовано для внешнего пользования | Да |
Отпечаток
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Electrical and Electronic Engineering
Цитировать
Biodegradation of magnetic nanoparticles in rat brain studied by Mössbauer spectroscopy. / Polikarpov, Dmitry M.; Gabbasov, Raul R.; Cherepanov, Valery M.; Chuev, Mikhail A.; Korshunov, Victor A.; Nikitin, Maxim P.; Deyev, Sergey M.; Panchenko, Vladislav Y.
В: IEEE Transactions on Magnetics, Том 49, № 1, 6392406, 2013, стр. 436-439.Результат исследований: Материалы для журнала › Статья
}
TY - JOUR
T1 - Biodegradation of magnetic nanoparticles in rat brain studied by Mössbauer spectroscopy
AU - Polikarpov, Dmitry M.
AU - Gabbasov, Raul R.
AU - Cherepanov, Valery M.
AU - Chuev, Mikhail A.
AU - Korshunov, Victor A.
AU - Nikitin, Maxim P.
AU - Deyev, Sergey M.
AU - Panchenko, Vladislav Y.
PY - 2013
Y1 - 2013
N2 - Superparamagnetic particles of Fe3 O4 in ferrofluid were injected transcranially in the ventricle of the rat brain. At three months after the injection the rat was sacrificed and the brain was investigated by Mössbauer spectroscopy and histological Perls Prussian blue method. Histological examination demonstrated increased concentration of blue areas in parenchyma and on the dura mater of the brain of experimental rat in comparison with the brain of control rat, indicating appearance in the brain of some undegradable compound of iron. Mössbauer spectra showed the presence in the ferrofluid of both Fe3 O4 nanoparticles and an additional chemical compound which contains ferric iron in the high-spin state. Comparison of the Mössbauer spectra of the ferrofluid, of the brain before injection and of the brain three months after injection shows that the Fe3 O4 nanoparticles were removed from the brain in three months. At the same time this additional chemical compound does not decompose and remains in the brain intact.
AB - Superparamagnetic particles of Fe3 O4 in ferrofluid were injected transcranially in the ventricle of the rat brain. At three months after the injection the rat was sacrificed and the brain was investigated by Mössbauer spectroscopy and histological Perls Prussian blue method. Histological examination demonstrated increased concentration of blue areas in parenchyma and on the dura mater of the brain of experimental rat in comparison with the brain of control rat, indicating appearance in the brain of some undegradable compound of iron. Mössbauer spectra showed the presence in the ferrofluid of both Fe3 O4 nanoparticles and an additional chemical compound which contains ferric iron in the high-spin state. Comparison of the Mössbauer spectra of the ferrofluid, of the brain before injection and of the brain three months after injection shows that the Fe3 O4 nanoparticles were removed from the brain in three months. At the same time this additional chemical compound does not decompose and remains in the brain intact.
KW - In vivo
KW - magnetic nanoparticles
KW - Mössbauer spectroscopy targeted drug delivery
KW - toxicology
UR - http://www.scopus.com/inward/record.url?scp=84871825427&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871825427&partnerID=8YFLogxK
U2 - 10.1109/TMAG.2012.2222875
DO - 10.1109/TMAG.2012.2222875
M3 - Article
AN - SCOPUS:84871825427
VL - 49
SP - 436
EP - 439
JO - IEEE Transactions on Magnetics
JF - IEEE Transactions on Magnetics
SN - 0018-9464
IS - 1
M1 - 6392406
ER -