Biocompatible materials based on self-assembling peptides on Ti25Nb10Zr alloy: Molecular structure and organization investigated by synchrotron radiation induced techniques

Valeria Secchi, Stefano Franchi, Marta Santi, Alina Vladescu, Mariana Braic, Tomáš Skála, Jaroslava Nováková, Monica Dettin, Annj Zamuner, Giovanna Iucci, Chiara Battocchio

Результат исследований: Материалы для журналаСтатья

5 Цитирования (Scopus)

Аннотация

In this work, we applied advanced Synchrotron Radiation (SR) induced techniques to the study of the chemisorption of the Self Assembling Peptide EAbuK16, i.e., H-Abu-Glu-Abu-Glu-Abu-Lys-Abu-Lys-Abu-Glu-Abu-Glu-Abu-Lys-Abu-Lys-NH2 that is able to spontaneously aggregate in anti-parallel β-sheet conformation, onto annealed Ti25Nb10Zr alloy surfaces. This synthetic amphiphilic oligopeptide is a good candidate to mimic extracellular matrix for bone prosthesis, since its β-sheets stack onto each other in a multilayer oriented nanostructure with internal pores of 5–200 nm size. To prepare the biomimetic material, Ti25Nb10Zr discs were treated with aqueous solutions of EAbuK16 at different pH values. Here we present the results achieved by performing SR-induced X-ray Photoelectron Spectroscopy (SR-XPS), angle-dependent Near Edge X-ray Absorption Fine Structure (NEXAFS) spectroscopy, FESEM and AFM imaging on Ti25Nb10Zr discs after incubation with self-assembling peptide solution at five different pH values, selected deliberately to investigate the best conditions for peptide immobilization.

Язык оригиналаАнглийский
Номер статьи148
ЖурналNanomaterials
Том8
Номер выпуска3
DOI
СостояниеОпубликовано - 1 мар 2018
Опубликовано для внешнего пользованияДа

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ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)

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