Association of ANKK1 polymorphism with antipsychotic-induced hyperprolactinemia

Olga Yu Fedorenko, Diana Z. Paderina, Anton J.M. Loonen, Ivan V. Pozhidaev, Anastasiia S. Boiko, Elena G. Kornetova, Nikolay A. Bokhan, Bob Wilffert, Svetlana A. Ivanova

Результат исследований: Материалы для журналаСтатья

Аннотация

Objective: Schizophrenia is a severe highly heritable mental disorder. Genetic polymorphisms of dopaminergic pathways are related to pathogenesis of drug response. Hyperprolactinemia (HPRL), a common adverse effect of antipsychotics, is attributed to blockade of dopamine D2 receptors. Ankyrin Repeat and Kinase Domain containing 1 (ANKK1) gene is closely related to Dopamine Receptor D2 type (DRD2) gene functioning. We examined whether the functional polymorphism rs2734849 in the ANKK1 gene is associated with antipsychotic-induced HPRL. Methods: We recruited 446 patients with schizophrenia from among the Russian population of the Siberian region. The polymorphism rs2734849 in the ANKK1 gene was genotyped with The MassARRAY® Analyzer 4 by Agena Bioscience™, using the kit SEQUENOM Consumables iPLEXGold 384. Genotype and allele frequencies were compared between groups of schizophrenia patients with and without HPRL using the χ2 test. Results: A comparison between schizophrenia patients with and without HPRL revealed significantly higher frequency of the C allele of the polymorphic variant rs2734849 in the ANKK1 gene in patients with HPRL as compared to the patients without it (χ2 = 3.70; p =.05; odds ratio [OR] = 1.30 [0.99–1.69]). Conclusion: The functional polymorphism rs2734849 in the ANKK1 gene was associated with HPRL in patients with schizophrenia.

Язык оригиналаАнглийский
Номер статьиe2737
ЖурналHuman Psychopharmacology
Том35
Номер выпуска4
DOI
СостояниеОпубликовано - 1 июл 2020

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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    Fedorenko, O. Y., Paderina, D. Z., Loonen, A. J. M., Pozhidaev, I. V., Boiko, A. S., Kornetova, E. G., Bokhan, N. A., Wilffert, B., & Ivanova, S. A. (2020). Association of ANKK1 polymorphism with antipsychotic-induced hyperprolactinemia. Human Psychopharmacology, 35(4), [e2737]. https://doi.org/10.1002/hup.2737