TY - JOUR
T1 - Arene-Ruthenium(II) Complexes Containing 11 H-Indeno[1,2- b]quinoxalin-11-one Derivatives and Tryptanthrin-6-oxime
T2 - Synthesis, Characterization, Cytotoxicity, and Catalytic Transfer Hydrogenation of Aryl Ketones
AU - Matveevskaya, Vladislava V.
AU - Pavlov, Dmitry I.
AU - Sukhikh, Taisiya S.
AU - Gushchin, Artem L.
AU - Ivanov, Alexander Yu
AU - Tennikova, Tatiana B.
AU - Sharoyko, Vladimir V.
AU - Baykov, Sergey V.
AU - Benassi, Enrico
AU - Potapov, Andrei S.
PY - 2020/5/19
Y1 - 2020/5/19
N2 - A series of novel mono- and binuclear arene-ruthenium(II) complexes [(p-cym)Ru(L)Cl] containing 11H-indeno[1,2-b]quinoxalin-11-one derivatives or tryptanthrin-6-oxime were synthesized and characterized by X-ray crystallography, IR, NMR spectroscopy, cyclic voltammetry, and elemental analysis. Theoretical calculations invoking singlet state geometry optimization, solvation effects, and noncovalent interactions were done using density functional theory (DFT). DFT calculations were also applied to evaluate the electronic properties, and time-dependent DFT was applied to clarify experimental UV-vis results. Cytotoxicity for cancerous and noncancerous human cell lines was evaluated with cell viability MTT assay. Complexes demonstrated a moderate cytotoxic effect toward cancerous human cell line PANC-1. The catalytic activity of the complexes was evaluated in transfer hydrogenation of aryl ketones. All complexes exhibited good catalytic activity and functional group tolerance.
AB - A series of novel mono- and binuclear arene-ruthenium(II) complexes [(p-cym)Ru(L)Cl] containing 11H-indeno[1,2-b]quinoxalin-11-one derivatives or tryptanthrin-6-oxime were synthesized and characterized by X-ray crystallography, IR, NMR spectroscopy, cyclic voltammetry, and elemental analysis. Theoretical calculations invoking singlet state geometry optimization, solvation effects, and noncovalent interactions were done using density functional theory (DFT). DFT calculations were also applied to evaluate the electronic properties, and time-dependent DFT was applied to clarify experimental UV-vis results. Cytotoxicity for cancerous and noncancerous human cell lines was evaluated with cell viability MTT assay. Complexes demonstrated a moderate cytotoxic effect toward cancerous human cell line PANC-1. The catalytic activity of the complexes was evaluated in transfer hydrogenation of aryl ketones. All complexes exhibited good catalytic activity and functional group tolerance.
UR - http://www.scopus.com/inward/record.url?scp=85084653075&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85084653075&partnerID=8YFLogxK
U2 - 10.1021/acsomega.0c01204
DO - 10.1021/acsomega.0c01204
M3 - Article
AN - SCOPUS:85084653075
VL - 5
SP - 11167
EP - 11179
JO - ACS Omega
JF - ACS Omega
SN - 2470-1343
IS - 19
ER -