Application of non-stop-flow differential pulse voltammetry at a tubular detector of silver solid amalgam for electrochemical determination of lomustine (CCNU)

Oksana Josypčuk, Jiří Barek, Bohdan Josypčuk

Результат исследований: Материалы для журналаСтатья

9 Цитирования (Scopus)

Аннотация

An application of the flow differential pulse voltammetry with tubular detector based on silver solid amalgam for determination of antineoplastic drug lomustine in pharmaceutical preparations is presented. The highest sensitivity was obtained in [0.10moldm-3 MES; 2.00moldm-3 NaCl; pH6.0]:EtOH (9:1) with flow rate 0.50mLmin-1, and the magnitude of the modulation amplitude -0.070V. The calibration dependence was linear in the range 1×10-6-1×10-4moldm-3 (R2=0.999). The limit of detection was 1.5×10-7moldm-3. This method was successfully used for determination of lomustine in real samples of chemotherapy drug CeeNU Lomustine 40mg.

Язык оригиналаАнглийский
Страницы (с-по)306-311
Число страниц6
ЖурналElectroanalysis
Том26
Номер выпуска2
DOI
СостояниеОпубликовано - 1 янв 2014
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry

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