Anticoagulant polyethylene terephthalate surface by plasma-mediated fucoidan immobilization

Kadir Ozaltin, Marian Lehocky, Petr Humpolicek, Jana Pelkova, Antonio Di Martino, Ilkay Karakurt, Petr Saha

Результат исследований: Материалы для журналаСтатья

2 Цитирования (Scopus)

Выдержка

Biomaterial-based blood clot formation is one of the biggest drawbacks of blood-contacting devices. To avoid blood clot formation, their surface must be tailored to increase hemocompatibility. Most synthetic polymeric biomaterials are inert and lack bonding sites for chemical agents to bond or tailor to the surface. In this study, polyethylene terephthalate was subjected to direct current air plasma treatment to enhance its surface energy and to bring oxidative functional binding sites. Marine-sourced anticoagulant sulphated polysaccharide fucoidan from Fucus vesiculosus was then immobilized onto the treated polyethylene terephthalate (PET) surface at different pH values to optimize chemical bonding behavior and therefore anticoagulant performance. Surface properties of samples were monitored using the water contact angle; chemical analyses were performed by FTIR and X-ray photoelectron spectroscopy (XPS) and their anticoagulant activity was tested by means of prothrombin time, activated partial thromboplastin time and thrombin time. On each of the fucoidan-immobilized surfaces, anticoagulation activity was performed by extending the thrombin time threshold and their pH 5 counterpart performed the best result compared to others.

Язык оригиналаАнглийский
Номер статьи750
ЖурналPolymers
Том11
Номер выпуска5
DOI
СостояниеОпубликовано - 1 мая 2019
Опубликовано для внешнего пользованияДа

Отпечаток

Polyethylene Terephthalates
Polyethylene terephthalates
Anticoagulants
Plasmas
Blood
Biocompatible Materials
Biomaterials
Thrombin
Thromboplastin
Prothrombin
Binding sites
Polysaccharides
Interfacial energy
Contact angle
Surface properties
X ray photoelectron spectroscopy
Binding Sites
fucoidan
Water
Air

ASJC Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics

Цитировать

Ozaltin, K., Lehocky, M., Humpolicek, P., Pelkova, J., Di Martino, A., Karakurt, I., & Saha, P. (2019). Anticoagulant polyethylene terephthalate surface by plasma-mediated fucoidan immobilization. Polymers, 11(5), [750]. https://doi.org/10.3390/polym11050750

Anticoagulant polyethylene terephthalate surface by plasma-mediated fucoidan immobilization. / Ozaltin, Kadir; Lehocky, Marian; Humpolicek, Petr; Pelkova, Jana; Di Martino, Antonio; Karakurt, Ilkay; Saha, Petr.

В: Polymers, Том 11, № 5, 750, 01.05.2019.

Результат исследований: Материалы для журналаСтатья

Ozaltin, K, Lehocky, M, Humpolicek, P, Pelkova, J, Di Martino, A, Karakurt, I & Saha, P 2019, 'Anticoagulant polyethylene terephthalate surface by plasma-mediated fucoidan immobilization', Polymers, том. 11, № 5, 750. https://doi.org/10.3390/polym11050750
Ozaltin K, Lehocky M, Humpolicek P, Pelkova J, Di Martino A, Karakurt I и соавт. Anticoagulant polyethylene terephthalate surface by plasma-mediated fucoidan immobilization. Polymers. 2019 Май 1;11(5). 750. https://doi.org/10.3390/polym11050750
Ozaltin, Kadir ; Lehocky, Marian ; Humpolicek, Petr ; Pelkova, Jana ; Di Martino, Antonio ; Karakurt, Ilkay ; Saha, Petr. / Anticoagulant polyethylene terephthalate surface by plasma-mediated fucoidan immobilization. В: Polymers. 2019 ; Том 11, № 5.
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