Anti-inflammatory activity of sodium salt of 4-(0-β-d-gluc0pyran0syl0xy)benz0ic acid

T. O. Murashko, I. V. Smirnov, A. A. Bondarev, A. A. Ivanov, P. S. Postnikov, A. O. Nemtsev, V. V. Udut

Результат исследования: Материалы для журналаСтатья

Аннотация

We have evaluated the anti-inflammatory activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid in comparison to well-known nonsteroidal anti-inflammatory drugs (NSAIDs). Carragcenan suspension (1%, 0.1 mL) was injected into subplantar region of the right hindpaw of rats (n - 12) pretreated (7 days and 60 min before carrageenan injection) intragastrically with methyl ester of 4(β-D-glucopyranosyloxy)benzoic acid (20 mg/kg), acetylsalicylic acid (20 mg/kg), 4-hydroxy benzoic acid (20 mg/kg), or vehicle (2 mL of purified water). Paw edema volume was measured plethysmographically at 1,2 and 4 h after carrageenan injection. The results showed that intragastric administration of the sodium salt of 4-(0-β-D-glucopyranosyIoxy)benzoic acid in a dose of 20 mg/kg for 7 days decreased the intensity of experimental inflammation.

Язык оригиналаАнглийский
Страницы (с... по...)26-28
Количество страниц3
ЖурналEksperimental'naya i Klinicheskaya Farmakologiya
Том79
Номер выпуска4
Статус публикацииОпубликовано - 1 янв 2016

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ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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