Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B

Andrew G. Ramstead, Igor A. Schepetkin, Kimberly Todd, James Loeffelholz, James G. Berardinelli, Mark T. Quinn, Mark A. Jutila

Результат исследований: Материалы для журналаСтатья

5 Цитирования (Scopus)

Выдержка

Several plant extracts, including certain polyphenols, prime innate lymphocytes and enhance responses to secondary stimuli. Oenothein B, a polyphenol isolated from Epilobium angustifolium and other plant sources, enhances IFNγ production by both bovine and human NK cells and T cells, alone and in response to secondary stimulation by cytokines or tumor cells. Innate immune cell responsiveness is known to be affected by aging, but whether polyphenol responses by these cells are also impacted by aging is not known. Therefore, we examined oenothein B responsiveness in T cells from cord blood, young, and adult donors. We found that oenothein B stimulates bovine and human T cells from individuals over a broad range of ages, as measured by increased IL-2Rα and CD69 expression. However, clear differences in induction of cytokine production by T cells were seen. In T cells from human cord blood and bovine calves, oenothein B was unable to induce IFNγ production. However, oenothein B induced IFNγ production by T cells from adult humans and cattle. In addition, oenothein B induced GM-CSF production by human adult T cells, but not cord blood T cells. Within the responsive T cell population, we found that CD45RO + memory T cells expressed more cytokines in response to oenothein B than CD45RO - T cells. In summary, our data suggest that the immunostimulation of T cells by oenothein B is influenced by age, particularly with respect to immune cytokine production.

Язык оригиналаАнглийский
Страницы (с-по)367-377
Число страниц11
ЖурналInternational Immunopharmacology
Том26
Номер выпуска2
DOI
СостояниеОпубликовано - 1 июн 2015
Опубликовано для внешнего пользованияДа

Отпечаток

T-Lymphocytes
Polyphenols
Fetal Blood
Cytokines
oenothein B
ellagitannin
Epilobium
Plant Extracts
Granulocyte-Macrophage Colony-Stimulating Factor
Natural Killer Cells
Young Adult
Immunization
Blood Cells
Tissue Donors
Lymphocytes
Population
Neoplasms

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology

Цитировать

Ramstead, A. G., Schepetkin, I. A., Todd, K., Loeffelholz, J., Berardinelli, J. G., Quinn, M. T., & Jutila, M. A. (2015). Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B. International Immunopharmacology, 26(2), 367-377. https://doi.org/10.1016/j.intimp.2015.04.008

Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B. / Ramstead, Andrew G.; Schepetkin, Igor A.; Todd, Kimberly; Loeffelholz, James; Berardinelli, James G.; Quinn, Mark T.; Jutila, Mark A.

В: International Immunopharmacology, Том 26, № 2, 01.06.2015, стр. 367-377.

Результат исследований: Материалы для журналаСтатья

Ramstead, AG, Schepetkin, IA, Todd, K, Loeffelholz, J, Berardinelli, JG, Quinn, MT & Jutila, MA 2015, 'Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B', International Immunopharmacology, том. 26, № 2, стр. 367-377. https://doi.org/10.1016/j.intimp.2015.04.008
Ramstead, Andrew G. ; Schepetkin, Igor A. ; Todd, Kimberly ; Loeffelholz, James ; Berardinelli, James G. ; Quinn, Mark T. ; Jutila, Mark A. / Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B. В: International Immunopharmacology. 2015 ; Том 26, № 2. стр. 367-377.
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AU - Todd, Kimberly

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AU - Berardinelli, James G.

AU - Quinn, Mark T.

AU - Jutila, Mark A.

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