Adalate effects on a clinical course of coronary heart disease, peripheral circulation and myocardial perfusion in patients with stenosing coronary atherosclerosis

Aim. To study adalate effects on the clinical picture, systemic microcirculation and myocardial blood flow in postmyocardial infarction patients. Materials and methods. Adalate was given for two weeks in a daily dose 30 mg to 17 patients with angina of effort who had survived macrofocal myocardial infarction. The examination was made with tetrapolar chest rheography, polarography, biomicroscopy, computed tomography. Results. Positive clinical changes were seen in 92% of the treated patients: the need in nitroglycerine reduced 1.8 times, muscular performance rose by 24%, skin O₂ tension increased by 37.5%, central hemodynamics, microcirculation and myocardial blood flow improved noticeably. Conclusion. Adalate has a good antianginal and antiischemic action due to positive hemodynamic effects.