Acetylene derivatives of heterocycles - 5. Some peculiarities in the synthesis of 4-ethynyl-3,5-dimethylpyrazole

M. S. Shvartsberg, S. F. Vasilevskii, R. Z. Sagdeev, I. L. Kotlyarevskii

Результат исследований: Материалы для журналаСтатья

Аннотация

1. A method was developed for the synthesis of 4-ethynyl-3,5-dimethylpyrazole from 4-acetyl-3,5-dimethylpyrazole. 2. The reaction of 4-acetyl-3,5-dimethylpyrazole with excess phosphorus pentachloride at elevated temperatures is anomalous and leads, in addition to replacement of the carbonyl oxygen by chlorine, to the replacement of hydrogen in the methyl group attached to the carbonyl group by chlorine. 3. On removal of hydrogen chloride with sodamide in liquid ammonia (3,5-dimethyl-4-pyrazolyl)-α,β-diehloroethylene gives a high yield of (3,5-dimethyl-4-pyrazolyl)-chloroacetylene.

Язык оригиналаАнглийский
Страницы (с-по)843-846
Число страниц4
ЖурналBulletin of the Academy of Sciences of the USSR Division of Chemical Science
Том18
Номер выпуска4
DOI
СостояниеОпубликовано - 1 апр 1969
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Chemistry(all)

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