A short and efficient synthesis of (+)-totarol

Victor Rogachev, Thorsten Löhl, Thomas Markert, Peter Metz

Результат исследования: Материалы для журналаСтатья

5 Цитирования (Scopus)


A concise route to multigram quantities of the antibacterial diterpene (+)-totarol (1) is reported. (-)-Sclareol (2) was converted to the target compound 1 using either a six- or a seven-step sequence, while only three steps were required to access (+)-totarol ( 1) starting from (+)-manool (9) or (+)-13-epi-manool (10), respectively. A novel one-pot intramolecular aldol condensation/α-alkylation protocol served as the key operation for streamlining the syntheses of 1.

Язык оригиналаАнглийский
Страницы (с... по...)172-180
Количество страниц9
Номер выпуска3
Статус публикацииОпубликовано - 23 янв 2012
Опубликовано для внешнего пользованияДа


ASJC Scopus subject areas

  • Organic Chemistry


Rogachev, V., Löhl, T., Markert, T., & Metz, P. (2012). A short and efficient synthesis of (+)-totarol. Arkivoc, 2012(3), 172-180. https://doi.org/10.3998/ark.5550190.0013.313