A novel far-red fluorescent xenograft model of ovarian carcinoma for preclinical evaluation of HER2-targeted immunotoxins

Tatiana Zdobnova, Evgeniya Sokolova, Oleg Stremovskiy, Dmitry Karpenko, William Telford, Ilya Turchin, Irina Balalaeva, Sergey Deyev

Результат исследований: Материалы для журналаСтатья

19 Цитирования (Scopus)

Аннотация

We have created a novel fluorescent model of a human ovarian carcinoma xenograft overexpressing receptor HER2, a promising molecular target of solid tumors. The model is based on a newly generated SKOV-kat cell line stably expressing far-red fluorescent protein Katushka. Katushka is most suitable for the in vivo imaging due to an optimal combination of high brightness and emission in the "window of tissue transparency". The relevance of the fluorescent model for the in vivo monitoring of tumor growth and response to treatment was demonstrated using a newly created HER2-targeted recombinant immunotoxin based on the 4D5scFv antibody and a fragment of the Pseudomonas exotoxin A.

Язык оригиналаАнглийский
Страницы (с-по)30919-30928
Число страниц10
ЖурналOncotarget
Том6
Номер выпуска31
DOI
СостояниеОпубликовано - 2015
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Oncology

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  • Цитировать

    Zdobnova, T., Sokolova, E., Stremovskiy, O., Karpenko, D., Telford, W., Turchin, I., Balalaeva, I., & Deyev, S. (2015). A novel far-red fluorescent xenograft model of ovarian carcinoma for preclinical evaluation of HER2-targeted immunotoxins. Oncotarget, 6(31), 30919-30928. https://doi.org/10.18632/oncotarget.5130