A molecular dynamic study of layered hydroxide induced depletion of mobile anions within the extracellular medium

Alexey A. Tsukanov, Sergey G. Psakhie

Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

Аннотация

The strong surface electric charge density of clay mineral host nanolayers enables their use as host-guest nanohybrids in many different areas of application. In particular, layered double hydroxides (LDH) of metals have found applications in medicine. Drug-LDH or gene-LDH nanohybrids are used for targeted delivery of biomedical agents to diseased cells or cancer cells. Fragments of the LDH host nanolayers may remain both within the cell and in the extracellular medium after drug delivery. How these charged nanosheets affect the cell electrostatics is still poorly understood. In the present paper, the idealized case of a single pure Mg2/Al-LDH nanolayer interacting with the extracellular anion environment was investigated to estimate the order of magnitude of a possible shift of the cell membrane equilibrium potential. An approximate dependence of the change in the chloride equilibrium membrane potential on the concentration of pure Mg2/Al-LDH nanosheets was determined.

Язык оригиналаАнглийский
Название основной публикацииAdvanced Materials with Hierarchical Structure for New Technologies and Reliable Structures
ИздательAmerican Institute of Physics Inc.
Том1683
ISBN (электронное издание)9780735413306
DOI
СостояниеОпубликовано - 27 окт 2015
СобытиеInternational Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2015 - Tomsk, Российская Федерация
Продолжительность: 21 сен 201525 сен 2015

Конференция

КонференцияInternational Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2015
СтранаРоссийская Федерация
ГородTomsk
Период21.9.1525.9.15

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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