A method for the efficient degradation of melphalan into nonmutagenic products

J. Barek, M. Castegnaro, C. Malaveille, I. Brouet, J. Zima

Результат исследований: Материалы для журналаСтатья

7 Цитирования (Scopus)

Выдержка

A new chemical method has been developed for the destruction of an antineoplastic agent melphalane in laboratory waste, based on its oxidation by potassium permanganate in sodium hydroxide medium. To monitor the efficiency of destruction, analytical methods based on UV spectrophotometry, differential pulse voltammetry on a glassy carbon rotating disk electrode, and HPLC coupled with UV spectrophotometry have been developed. It has been demonstrated that the proposed method of destruction is highly efficient (more than 99.8% destruction) and the corresponding degradation products were found to be nonmutagenic to Salmonella typhimurium strains TA98, TA100, and TA1535, in both the presence and the absence of a rat liver S9 activation system.

Язык оригиналаАнглийский
Страницы (с-по)192-197
Число страниц6
ЖурналMicrochemical Journal
Том36
Номер выпуска2
DOI
СостояниеОпубликовано - 1 янв 1987
Опубликовано для внешнего пользованияДа

Отпечаток

Melphalan
Spectrophotometry
Potassium Permanganate
Degradation
Sodium Hydroxide
Salmonella
Glassy carbon
Rotating disks
Voltammetry
Liver
Antineoplastic Agents
Rats
Chemical activation
Oxidation
Electrodes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

Цитировать

A method for the efficient degradation of melphalan into nonmutagenic products. / Barek, J.; Castegnaro, M.; Malaveille, C.; Brouet, I.; Zima, J.

В: Microchemical Journal, Том 36, № 2, 01.01.1987, стр. 192-197.

Результат исследований: Материалы для журналаСтатья

Barek, J. ; Castegnaro, M. ; Malaveille, C. ; Brouet, I. ; Zima, J. / A method for the efficient degradation of melphalan into nonmutagenic products. В: Microchemical Journal. 1987 ; Том 36, № 2. стр. 192-197.
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