TY - JOUR
T1 - 4-Iodoantipyrine synthesized by means of solid-state mechanical activation
AU - Krasnokutskaya, E. A.
AU - Trusova, M. E.
AU - Gibert, N. S.
AU - Filimonov, V. D.
PY - 2007/3
Y1 - 2007/3
N2 - Antipyrine and its benzenesulfonate were iodinated by solid-state mechanical activation (in the absence of solvent) under the action of iodine, iodine chloride, Me4N+ICl2
-, and Et4N+ICl2
- with the formation of 4-iodoantipyrine. The proposed process does not require organic solvents and meets all Green Chemistry demands. The best results were achieved with the use of tetraalkylammonium salts Me4N+ICl2 - and Et4N+ICl2
-.
AB - Antipyrine and its benzenesulfonate were iodinated by solid-state mechanical activation (in the absence of solvent) under the action of iodine, iodine chloride, Me4N+ICl2
-, and Et4N+ICl2
- with the formation of 4-iodoantipyrine. The proposed process does not require organic solvents and meets all Green Chemistry demands. The best results were achieved with the use of tetraalkylammonium salts Me4N+ICl2 - and Et4N+ICl2
-.
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U2 - 10.1007/s11094-007-0034-1
DO - 10.1007/s11094-007-0034-1
M3 - Article
AN - SCOPUS:35148860205
VL - 41
SP - 154
EP - 156
JO - Pharmaceutical Chemistry Journal
JF - Pharmaceutical Chemistry Journal
SN - 0091-150X
IS - 3
ER -