Voltammetry at a Hanging Mercury Drop Electrode as a Tool for the Study of the Interaction of Double-stranded DNA with Genotoxic 4-Nitrobiphenyl

Eva Horakova, Jiri Barek, Vlastimil Vyskocil

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Differential pulse voltammetry, cyclic voltammetry, alternating current voltammetry, and chronocoulometry at a hanging mercury drop electrode (HMDE) and DNA modified HMDE were used for the study of the interaction of 4-nitrobiphenyl (4-NBP) with double-stranded DNA and for the detection of DNA damage caused by its interaction with 4-NBP. Moreover, the interaction of DNA with intermediates of the 4-NBP reduction and with 4-aminobiphenyl, a metabolite of 4-NBP, was investigated. The mechanism of the electrochemical reduction of 4-NBP was investigated using CV, too. It was found that the reduction of 4-NBP is controlled by both diffusion and adsorption. The rate constant of the reduction and the diffusion coefficient were calculated as well.

Original languageEnglish
Pages (from-to)2760-2770
Number of pages11
JournalElectroanalysis
Volume28
Issue number11
DOIs
Publication statusPublished - 1 Nov 2016
Externally publishedYes

Keywords

  • 4-aminobiphenyl
  • 4-nitrobiphenyl
  • DNA
  • hanging mercury drop electrode
  • interaction
  • voltammetry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry

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