Voltammetric sensing system for the detection of cholesterol based on the Ni-bisurea-pyrographite composite

Anastasia A. Lukina, Daniar V. Ismailov, Alexander P. Ilyin, Ksenia V. Derina, Elena I. Korotkova

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cholesterol plays a crucial role in the human body. High cholesterol level in blood is a marker of CVDs. Therefore, cholesterol determination techniques are necessary for clinical practice. Currently used cholesterol determination techniques involve enzymes or expensive and complicated equipment. Electrochemical techniques are widely spread in test-systems and sensors construction. Novel modification procedure for enzymeless cholesterol determination is suggested in this study. The electrochemical behavior of cholesterol on modified electrode was studied with the usage of cyclic and differential pulse voltammetry. Obtained concentration range is linear from 0.1 up to 100 mM a conditions close to physiological (pH=6.86) with a quantification limit of 0.01 mM. Besides, the electrode surface morphology and pH-effect were studied. The developed technique is promising for the rapid determination of total cholesterol in blood.

Original languageEnglish
Title of host publicationHigh Technology
Subtitle of host publicationResearch and Applications 2017
EditorsGeorgii E. Osokin, Ekaterina A. Kulinich
PublisherTrans Tech Publications Ltd
Pages250-255
Number of pages6
ISBN (Print)9783035712810
DOIs
Publication statusPublished - 1 Jan 2018
Event6th International Conference for Young Scientists High Technology: Research and Applications, HTRA 2017 - Tomsk, Russian Federation
Duration: 27 Nov 201729 Nov 2017

Publication series

NameKey Engineering Materials
Volume769 KEM
ISSN (Print)1013-9826

Conference

Conference6th International Conference for Young Scientists High Technology: Research and Applications, HTRA 2017
CountryRussian Federation
CityTomsk
Period27.11.1729.11.17

Keywords

  • Cholesterol
  • Glycoluril derivatives
  • Modified electrode
  • Nickel nanopowder
  • Voltammetry

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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