Abstract
The voltammetric behavior of nifedipine (NFD) has been studied with two different types of working electrodes (hanging mercury drop mini-electrode (HMDmE) and mercury meniscus silver solid amalgam electrode (m-AgSAE)) using differential pulse voltammetry (DPV). The optimal conditions for DPV determination are: a mixture of Britton-Robinson (BR) buffer pH 8 with methanol in three different ratios (1:1, 9:1, 99:1), respectively, in the concentration range of 0.2 to 20 μmol/L. The limit of quantification (LQ) was found to be 0.12 μmol/L (HMDmE) and 1.2 μmol/L (m-AgSAE). Attempts to increase the sensitivity using adsorptive stripping DPV at both HMDmE and m-AgSAE were not successful. Using the optimum conditions, the practical application of the newly developed method has been verified on the determination of NFD in spiked samples of drinking and river water.
| Original language | English |
|---|---|
| Pages (from-to) | 4571-4584 |
| Number of pages | 14 |
| Journal | International Journal of Electrochemical Science |
| Volume | 10 |
| Issue number | 6 |
| Publication status | Published - 1 Jan 2015 |
| Externally published | Yes |
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Keywords
- Differential pulse voltammetry
- Hanging mercury drop mini-electrode
- Mercury meniscus silver solid amalgam electrode
- Nifedipine
ASJC Scopus subject areas
- Electrochemistry
Cite this
Voltammetric determination of nifedipine at a hanging mercury drop electrode and a mercury meniscus modified silver amalgam electrode. / Wirzal, Mohd Dzul Hakim; Yusoff, Abdull Rahim Mohd; Zima, Jiri; Barek, Jiri.
In: International Journal of Electrochemical Science, Vol. 10, No. 6, 01.01.2015, p. 4571-4584.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Voltammetric determination of nifedipine at a hanging mercury drop electrode and a mercury meniscus modified silver amalgam electrode
AU - Wirzal, Mohd Dzul Hakim
AU - Yusoff, Abdull Rahim Mohd
AU - Zima, Jiri
AU - Barek, Jiri
PY - 2015/1/1
Y1 - 2015/1/1
N2 - The voltammetric behavior of nifedipine (NFD) has been studied with two different types of working electrodes (hanging mercury drop mini-electrode (HMDmE) and mercury meniscus silver solid amalgam electrode (m-AgSAE)) using differential pulse voltammetry (DPV). The optimal conditions for DPV determination are: a mixture of Britton-Robinson (BR) buffer pH 8 with methanol in three different ratios (1:1, 9:1, 99:1), respectively, in the concentration range of 0.2 to 20 μmol/L. The limit of quantification (LQ) was found to be 0.12 μmol/L (HMDmE) and 1.2 μmol/L (m-AgSAE). Attempts to increase the sensitivity using adsorptive stripping DPV at both HMDmE and m-AgSAE were not successful. Using the optimum conditions, the practical application of the newly developed method has been verified on the determination of NFD in spiked samples of drinking and river water.
AB - The voltammetric behavior of nifedipine (NFD) has been studied with two different types of working electrodes (hanging mercury drop mini-electrode (HMDmE) and mercury meniscus silver solid amalgam electrode (m-AgSAE)) using differential pulse voltammetry (DPV). The optimal conditions for DPV determination are: a mixture of Britton-Robinson (BR) buffer pH 8 with methanol in three different ratios (1:1, 9:1, 99:1), respectively, in the concentration range of 0.2 to 20 μmol/L. The limit of quantification (LQ) was found to be 0.12 μmol/L (HMDmE) and 1.2 μmol/L (m-AgSAE). Attempts to increase the sensitivity using adsorptive stripping DPV at both HMDmE and m-AgSAE were not successful. Using the optimum conditions, the practical application of the newly developed method has been verified on the determination of NFD in spiked samples of drinking and river water.
KW - Differential pulse voltammetry
KW - Hanging mercury drop mini-electrode
KW - Mercury meniscus silver solid amalgam electrode
KW - Nifedipine
UR - http://www.scopus.com/inward/record.url?scp=84930159071&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930159071&partnerID=8YFLogxK
M3 - Article
VL - 10
SP - 4571
EP - 4584
JO - International Journal of Electrochemical Science
JF - International Journal of Electrochemical Science
SN - 1452-3981
IS - 6
ER -