Voltammetric determination of nifedipine at a hanging mercury drop electrode and a mercury meniscus modified silver amalgam electrode

Mohd Dzul Hakim Wirzal, Abdull Rahim Mohd Yusoff, Jiri Zima, Jiri Barek

Research output: Contribution to journal › Article

Abstract

The voltammetric behavior of nifedipine (NFD) has been studied with two different types of working electrodes (hanging mercury drop mini-electrode (HMDmE) and mercury meniscus silver solid amalgam electrode (m-AgSAE)) using differential pulse voltammetry (DPV). The optimal conditions for DPV determination are: a mixture of Britton-Robinson (BR) buffer pH 8 with methanol in three different ratios (1:1, 9:1, 99:1), respectively, in the concentration range of 0.2 to 20 μmol/L. The limit of quantification (L_Q) was found to be 0.12 μmol/L (HMDmE) and 1.2 μmol/L (m-AgSAE). Attempts to increase the sensitivity using adsorptive stripping DPV at both HMDmE and m-AgSAE were not successful. Using the optimum conditions, the practical application of the newly developed method has been verified on the determination of NFD in spiked samples of drinking and river water.

Original language	English
Pages (from-to)	4571-4584
Number of pages	14
Journal	International Journal of Electrochemical Science
Volume	10
Issue number	6
Publication status	Published - 1 Jan 2015
Externally published	Yes

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Keywords

Differential pulse voltammetry
Hanging mercury drop mini-electrode
Mercury meniscus silver solid amalgam electrode
Nifedipine

ASJC Scopus subject areas

Electrochemistry

Cite this

Wirzal, M. D. H., Yusoff, A. R. M., Zima, J., & Barek, J. (2015). Voltammetric determination of nifedipine at a hanging mercury drop electrode and a mercury meniscus modified silver amalgam electrode. International Journal of Electrochemical Science, 10(6), 4571-4584.

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title = "Voltammetric determination of nifedipine at a hanging mercury drop electrode and a mercury meniscus modified silver amalgam electrode",

abstract = "The voltammetric behavior of nifedipine (NFD) has been studied with two different types of working electrodes (hanging mercury drop mini-electrode (HMDmE) and mercury meniscus silver solid amalgam electrode (m-AgSAE)) using differential pulse voltammetry (DPV). The optimal conditions for DPV determination are: a mixture of Britton-Robinson (BR) buffer pH 8 with methanol in three different ratios (1:1, 9:1, 99:1), respectively, in the concentration range of 0.2 to 20 μmol/L. The limit of quantification (LQ) was found to be 0.12 μmol/L (HMDmE) and 1.2 μmol/L (m-AgSAE). Attempts to increase the sensitivity using adsorptive stripping DPV at both HMDmE and m-AgSAE were not successful. Using the optimum conditions, the practical application of the newly developed method has been verified on the determination of NFD in spiked samples of drinking and river water.",

keywords = "Differential pulse voltammetry, Hanging mercury drop mini-electrode, Mercury meniscus silver solid amalgam electrode, Nifedipine",

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T1 - Voltammetric determination of nifedipine at a hanging mercury drop electrode and a mercury meniscus modified silver amalgam electrode

AU - Wirzal, Mohd Dzul Hakim

AU - Yusoff, Abdull Rahim Mohd

AU - Zima, Jiri

AU - Barek, Jiri

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The voltammetric behavior of nifedipine (NFD) has been studied with two different types of working electrodes (hanging mercury drop mini-electrode (HMDmE) and mercury meniscus silver solid amalgam electrode (m-AgSAE)) using differential pulse voltammetry (DPV). The optimal conditions for DPV determination are: a mixture of Britton-Robinson (BR) buffer pH 8 with methanol in three different ratios (1:1, 9:1, 99:1), respectively, in the concentration range of 0.2 to 20 μmol/L. The limit of quantification (LQ) was found to be 0.12 μmol/L (HMDmE) and 1.2 μmol/L (m-AgSAE). Attempts to increase the sensitivity using adsorptive stripping DPV at both HMDmE and m-AgSAE were not successful. Using the optimum conditions, the practical application of the newly developed method has been verified on the determination of NFD in spiked samples of drinking and river water.

AB - The voltammetric behavior of nifedipine (NFD) has been studied with two different types of working electrodes (hanging mercury drop mini-electrode (HMDmE) and mercury meniscus silver solid amalgam electrode (m-AgSAE)) using differential pulse voltammetry (DPV). The optimal conditions for DPV determination are: a mixture of Britton-Robinson (BR) buffer pH 8 with methanol in three different ratios (1:1, 9:1, 99:1), respectively, in the concentration range of 0.2 to 20 μmol/L. The limit of quantification (LQ) was found to be 0.12 μmol/L (HMDmE) and 1.2 μmol/L (m-AgSAE). Attempts to increase the sensitivity using adsorptive stripping DPV at both HMDmE and m-AgSAE were not successful. Using the optimum conditions, the practical application of the newly developed method has been verified on the determination of NFD in spiked samples of drinking and river water.

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KW - Hanging mercury drop mini-electrode

KW - Mercury meniscus silver solid amalgam electrode

KW - Nifedipine

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