Voltammetric determination of nifedipine at a hanging mercury drop electrode and a mercury meniscus modified silver amalgam electrode

Abstract

The voltammetric behavior of nifedipine (NFD) has been studied with two different types of working electrodes (hanging mercury drop mini-electrode (HMDmE) and mercury meniscus silver solid amalgam electrode (m-AgSAE)) using differential pulse voltammetry (DPV). The optimal conditions for DPV determination are: a mixture of Britton-Robinson (BR) buffer pH 8 with methanol in three different ratios (1:1, 9:1, 99:1), respectively, in the concentration range of 0.2 to 20 μmol/L. The limit of quantification (L_Q) was found to be 0.12 μmol/L (HMDmE) and 1.2 μmol/L (m-AgSAE). Attempts to increase the sensitivity using adsorptive stripping DPV at both HMDmE and m-AgSAE were not successful. Using the optimum conditions, the practical application of the newly developed method has been verified on the determination of NFD in spiked samples of drinking and river water.

Original language	English
Pages (from-to)	4571-4584
Number of pages	14
Journal	International Journal of Electrochemical Science
Volume	10
Issue number	6
Publication status	Published - 1 Jan 2015
Externally published	Yes

Keywords

Differential pulse voltammetry
Hanging mercury drop mini-electrode
Mercury meniscus silver solid amalgam electrode
Nifedipine

ASJC Scopus subject areas

Electrochemistry

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Voltammetric determination of nifedipine at a hanging mercury drop electrode and a mercury meniscus modified silver amalgam electrode. / Wirzal, Mohd Dzul Hakim; Yusoff, Abdull Rahim Mohd; Zima, Jiri; Barek, Jiri.

In: International Journal of Electrochemical Science, Vol. 10, No. 6, 01.01.2015, p. 4571-4584.

Research output: Contribution to journal › Article › peer-review

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title = "Voltammetric determination of nifedipine at a hanging mercury drop electrode and a mercury meniscus modified silver amalgam electrode",

abstract = "The voltammetric behavior of nifedipine (NFD) has been studied with two different types of working electrodes (hanging mercury drop mini-electrode (HMDmE) and mercury meniscus silver solid amalgam electrode (m-AgSAE)) using differential pulse voltammetry (DPV). The optimal conditions for DPV determination are: a mixture of Britton-Robinson (BR) buffer pH 8 with methanol in three different ratios (1:1, 9:1, 99:1), respectively, in the concentration range of 0.2 to 20 μmol/L. The limit of quantification (LQ) was found to be 0.12 μmol/L (HMDmE) and 1.2 μmol/L (m-AgSAE). Attempts to increase the sensitivity using adsorptive stripping DPV at both HMDmE and m-AgSAE were not successful. Using the optimum conditions, the practical application of the newly developed method has been verified on the determination of NFD in spiked samples of drinking and river water.",

keywords = "Differential pulse voltammetry, Hanging mercury drop mini-electrode, Mercury meniscus silver solid amalgam electrode, Nifedipine",

author = "Wirzal, {Mohd Dzul Hakim} and Yusoff, {Abdull Rahim Mohd} and Jiri Zima and Jiri Barek",

year = "2015",

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T1 - Voltammetric determination of nifedipine at a hanging mercury drop electrode and a mercury meniscus modified silver amalgam electrode

AU - Wirzal, Mohd Dzul Hakim

AU - Yusoff, Abdull Rahim Mohd

AU - Zima, Jiri

AU - Barek, Jiri

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The voltammetric behavior of nifedipine (NFD) has been studied with two different types of working electrodes (hanging mercury drop mini-electrode (HMDmE) and mercury meniscus silver solid amalgam electrode (m-AgSAE)) using differential pulse voltammetry (DPV). The optimal conditions for DPV determination are: a mixture of Britton-Robinson (BR) buffer pH 8 with methanol in three different ratios (1:1, 9:1, 99:1), respectively, in the concentration range of 0.2 to 20 μmol/L. The limit of quantification (LQ) was found to be 0.12 μmol/L (HMDmE) and 1.2 μmol/L (m-AgSAE). Attempts to increase the sensitivity using adsorptive stripping DPV at both HMDmE and m-AgSAE were not successful. Using the optimum conditions, the practical application of the newly developed method has been verified on the determination of NFD in spiked samples of drinking and river water.

AB - The voltammetric behavior of nifedipine (NFD) has been studied with two different types of working electrodes (hanging mercury drop mini-electrode (HMDmE) and mercury meniscus silver solid amalgam electrode (m-AgSAE)) using differential pulse voltammetry (DPV). The optimal conditions for DPV determination are: a mixture of Britton-Robinson (BR) buffer pH 8 with methanol in three different ratios (1:1, 9:1, 99:1), respectively, in the concentration range of 0.2 to 20 μmol/L. The limit of quantification (LQ) was found to be 0.12 μmol/L (HMDmE) and 1.2 μmol/L (m-AgSAE). Attempts to increase the sensitivity using adsorptive stripping DPV at both HMDmE and m-AgSAE were not successful. Using the optimum conditions, the practical application of the newly developed method has been verified on the determination of NFD in spiked samples of drinking and river water.

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KW - Mercury meniscus silver solid amalgam electrode

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