Voltammetric determination of nifedipine at a hanging mercury drop electrode and a mercury meniscus modified silver amalgam electrode

Mohd Dzul Hakim Wirzal, Abdull Rahim Mohd Yusoff, Jiri Zima, Jiri Barek

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4 Citations (Scopus)


The voltammetric behavior of nifedipine (NFD) has been studied with two different types of working electrodes (hanging mercury drop mini-electrode (HMDmE) and mercury meniscus silver solid amalgam electrode (m-AgSAE)) using differential pulse voltammetry (DPV). The optimal conditions for DPV determination are: a mixture of Britton-Robinson (BR) buffer pH 8 with methanol in three different ratios (1:1, 9:1, 99:1), respectively, in the concentration range of 0.2 to 20 μmol/L. The limit of quantification (LQ) was found to be 0.12 μmol/L (HMDmE) and 1.2 μmol/L (m-AgSAE). Attempts to increase the sensitivity using adsorptive stripping DPV at both HMDmE and m-AgSAE were not successful. Using the optimum conditions, the practical application of the newly developed method has been verified on the determination of NFD in spiked samples of drinking and river water.

Original languageEnglish
Pages (from-to)4571-4584
Number of pages14
JournalInternational Journal of Electrochemical Science
Issue number6
Publication statusPublished - 1 Jan 2015
Externally publishedYes



  • Differential pulse voltammetry
  • Hanging mercury drop mini-electrode
  • Mercury meniscus silver solid amalgam electrode
  • Nifedipine

ASJC Scopus subject areas

  • Electrochemistry

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