Voltammetric determination of flutamide and its metabolite 4-nitro-3-trifluoromethylaniline at a hanging mercury drop minielectrode

Karolina Pecková, Markéta Průchová, Josino C. Moreira, Jiří Barek, Jan Fischer, Vlastimil Vyskočil

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Optimum conditions were found for direct current and differential pulse voltammetric determination of anticancer drug Flutamide and its main metabolite 4-nitro-3-trifluoromethylaniline on a hanging mercury drop minielectrode in mixed Britton-Robinson buffer (pH 12.0)-methanol (9:1) or 0.01 M NaOH-methanol (9:1) media with limit of quantitation ca. 10 -7 mol l -1. It was proved that the newly developed method is applicable for the determination of Flutamide in pharmaceutical formulations and for the determination of both Flutamide and 4-nitro-3-trifluoromethylaniline in urine either directly with limit of quantitation ca. 10 -5 mol l -1 or after solid phase extraction with limit of quantitation in the 10 -7 mol l -1 concentration range. The sufficient peak potential difference of the two substances suggests the possibility of the analysis of their mixtures.

Original languageEnglish
Pages (from-to)1811-1823
Number of pages13
JournalCollection of Czechoslovak Chemical Communications
Volume76
Issue number12
DOIs
Publication statusPublished - 1 Dec 2011
Externally publishedYes

Keywords

  • 4-Nitro-3-trifluoromethylaniline
  • Analytical methods
  • Antitumor agents
  • Flutamide
  • Hanging mercury drop minielectrode
  • Solid phase extraction
  • Urine
  • Voltammetry

ASJC Scopus subject areas

  • Chemistry(all)

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