Voltammetric Determination of Carcinogenic Derivatives of Pyrene Using a Boron-Doped Diamond Film Electrode

Oksana Yosypchuk, Jiří Barek, Vlastimil Vyskočil

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Based on the study of voltammetric behavior of carcinogenic 1-nitropyrene (1-NP), 1-aminopyrene (1-AP), and 1-hydroxypyrene (1-HP), optimum conditions have been found for the determination of these analytes by differential pulse voltammetry (DPV) at a boron-doped diamond film electrode. The optimum medium was methanol-Britton-Robinson buffer (BR buffer) pH 3.0 (70:30) for 1-NP and 1-AP, and methanol-BR buffer pH 5.0 (70:30) for 1-HP. Concentration dependences of the DPV response were measured in the range 1 · 10 -6-1 · 10 -4 mol dm -3 (R = -0.9998) with the limit of detection (LOD) 3 · 10 -7 mol dm -3 for 1-NP, 1 · 10 -7-1 · 10 -5 mol dm -3 (R = 0.9971) with LOD 6 · 10 -8 mol dm -3 for 1-AP, and 1 · 10 -7-1 · 10 -5 mol dm -3 (R = 0.9934) with LOD 1 · 10 -7 mol dm -3 for 1-HP. Simultaneous determination of 1-NP and 1-AP in a mixture was tested in the methanol-BR buffer pH 3.0 (70:30) medium as well. The content of 1-AP in the concentration range from 1 · 10 -6 to 1 · 10 -4 mol dm -3 had no effect on the sensitivity of the determination of 1-NP, and vice versa. Due to the close peak potentials of 1-AP and 1-HP, the direct determination of their mixture using voltammetric methods is impossible.

Original languageEnglish
Pages (from-to)449-459
Number of pages11
JournalAnalytical Letters
Volume45
Issue number5-6
DOIs
Publication statusPublished - 1 Mar 2012
Externally publishedYes

Fingerprint

1-nitropyrene
Diamond
Boron
Diamond films
Pyrene
Electrodes
Methanol
Voltammetry
Derivatives
Limit of Detection
Buffers
1-aminopyrene
pyrene

Keywords

  • 1-Aminopyrene
  • 1-Hydroxypyrene
  • 1-Nitropyrene
  • Boron-doped diamond film electrode
  • Chemical carcinogens
  • Differential pulse voltammetry
  • Solid phase extraction

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Spectroscopy
  • Clinical Biochemistry
  • Biochemistry, medical
  • Electrochemistry

Cite this

Voltammetric Determination of Carcinogenic Derivatives of Pyrene Using a Boron-Doped Diamond Film Electrode. / Yosypchuk, Oksana; Barek, Jiří; Vyskočil, Vlastimil.

In: Analytical Letters, Vol. 45, No. 5-6, 01.03.2012, p. 449-459.

Research output: Contribution to journalArticle

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AB - Based on the study of voltammetric behavior of carcinogenic 1-nitropyrene (1-NP), 1-aminopyrene (1-AP), and 1-hydroxypyrene (1-HP), optimum conditions have been found for the determination of these analytes by differential pulse voltammetry (DPV) at a boron-doped diamond film electrode. The optimum medium was methanol-Britton-Robinson buffer (BR buffer) pH 3.0 (70:30) for 1-NP and 1-AP, and methanol-BR buffer pH 5.0 (70:30) for 1-HP. Concentration dependences of the DPV response were measured in the range 1 · 10 -6-1 · 10 -4 mol dm -3 (R = -0.9998) with the limit of detection (LOD) 3 · 10 -7 mol dm -3 for 1-NP, 1 · 10 -7-1 · 10 -5 mol dm -3 (R = 0.9971) with LOD 6 · 10 -8 mol dm -3 for 1-AP, and 1 · 10 -7-1 · 10 -5 mol dm -3 (R = 0.9934) with LOD 1 · 10 -7 mol dm -3 for 1-HP. Simultaneous determination of 1-NP and 1-AP in a mixture was tested in the methanol-BR buffer pH 3.0 (70:30) medium as well. The content of 1-AP in the concentration range from 1 · 10 -6 to 1 · 10 -4 mol dm -3 had no effect on the sensitivity of the determination of 1-NP, and vice versa. Due to the close peak potentials of 1-AP and 1-HP, the direct determination of their mixture using voltammetric methods is impossible.

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