Voltammetric Determination of 5-nitroindazole using a Bismuth Bulk Electrode

Vit Prchal, Anita Ottenschlagerova, Vlastimil Vyskocil, Jiri Barek

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8 Citations (Scopus)

Abstract

A rapid simple fabrication method for the bismuth bulk working electrode is reported using a Pasteur pipette tip filled with molten bismuth to form a disk. The applicability of the newly developed electrode was verified by differential pulse voltammetric determination of 5-nitroindazole, which is a reagent for organic synthesis. The 5-nitroindazole shows high toxicity against parasites from the Trypanosomatidae family and it is a proven mutagen for bacterial cultures. A Britton-Robinson buffer of pH 8.0 was chosen as the optimal medium for this determination. The calibration curve was measured from 2 to 100 micromoles per liter (r = −0.9989) with limits of detection and quantification of 0.20 and 0.67 micromole per liter, respectively. The developed method was successfully applied for the analysis of drinking and river water.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalAnalytical Letters
Volume49
Issue number1
DOIs
Publication statusPublished - 2 Jan 2016
Externally publishedYes

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Keywords

  • 5-Nitroindazole
  • bismuth bulk electrode
  • differential pulse voltammetry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Electrochemistry
  • Spectroscopy

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