Voltammetric and amperometric determination of selected catecholamine metabolites using glassy carbon paste electrode

Hana Dejmkova, Hana Adamkova, Jiri Barek, Jiri Zima

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Abstract: Two methods, using glassy carbon paste electrode for the simultaneous determination homovanillic acid and vanillylmandelic acid, of two catecholamine neurotransmitter metabolites that can serve as biomarkers of several oncological diseases, were developed, based on differential pulse voltammetry and HPLC with amperometric detection. Low selectivity of the voltammetric method was limiting for the determination in urine samples; inclusion of chromatographic separation enabled the application in complex matrix. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)511-515
Number of pages5
JournalMonatshefte fur Chemie
Volume148
Issue number3
DOIs
Publication statusPublished - 1 Mar 2017
Externally publishedYes

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Keywords

  • Electrochemistry
  • High pressure liquid chromatography
  • Homovanillic acid
  • Vanillylmandelic acid
  • Voltammetry

ASJC Scopus subject areas

  • Chemistry(all)

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