Voltammetric and amperometric determination of selected catecholamine metabolites using glassy carbon paste electrode

Abstract

Abstract: Two methods, using glassy carbon paste electrode for the simultaneous determination homovanillic acid and vanillylmandelic acid, of two catecholamine neurotransmitter metabolites that can serve as biomarkers of several oncological diseases, were developed, based on differential pulse voltammetry and HPLC with amperometric detection. Low selectivity of the voltammetric method was limiting for the determination in urine samples; inclusion of chromatographic separation enabled the application in complex matrix. Graphical abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	511-515
Number of pages	5
Journal	Monatshefte fur Chemie
Volume	148
Issue number	3
DOIs	https://doi.org/10.1007/s00706-016-1902-8
Publication status	Published - 1 Mar 2017
Externally published	Yes

Keywords

Electrochemistry
High pressure liquid chromatography
Homovanillic acid
Vanillylmandelic acid
Voltammetry

ASJC Scopus subject areas

Chemistry(all)

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10.1007/s00706-016-1902-8

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title = "Voltammetric and amperometric determination of selected catecholamine metabolites using glassy carbon paste electrode",

abstract = "Abstract: Two methods, using glassy carbon paste electrode for the simultaneous determination homovanillic acid and vanillylmandelic acid, of two catecholamine neurotransmitter metabolites that can serve as biomarkers of several oncological diseases, were developed, based on differential pulse voltammetry and HPLC with amperometric detection. Low selectivity of the voltammetric method was limiting for the determination in urine samples; inclusion of chromatographic separation enabled the application in complex matrix. Graphical abstract: [Figure not available: see fulltext.]",

keywords = "Electrochemistry, High pressure liquid chromatography, Homovanillic acid, Vanillylmandelic acid, Voltammetry",

author = "Hana Dejmkova and Hana Adamkova and Jiri Barek and Jiri Zima",

year = "2017",

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doi = "10.1007/s00706-016-1902-8",

language = "English",

volume = "148",

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TY - JOUR

T1 - Voltammetric and amperometric determination of selected catecholamine metabolites using glassy carbon paste electrode

AU - Dejmkova, Hana

AU - Adamkova, Hana

AU - Barek, Jiri

AU - Zima, Jiri

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Abstract: Two methods, using glassy carbon paste electrode for the simultaneous determination homovanillic acid and vanillylmandelic acid, of two catecholamine neurotransmitter metabolites that can serve as biomarkers of several oncological diseases, were developed, based on differential pulse voltammetry and HPLC with amperometric detection. Low selectivity of the voltammetric method was limiting for the determination in urine samples; inclusion of chromatographic separation enabled the application in complex matrix. Graphical abstract: [Figure not available: see fulltext.]

AB - Abstract: Two methods, using glassy carbon paste electrode for the simultaneous determination homovanillic acid and vanillylmandelic acid, of two catecholamine neurotransmitter metabolites that can serve as biomarkers of several oncological diseases, were developed, based on differential pulse voltammetry and HPLC with amperometric detection. Low selectivity of the voltammetric method was limiting for the determination in urine samples; inclusion of chromatographic separation enabled the application in complex matrix. Graphical abstract: [Figure not available: see fulltext.]

KW - Electrochemistry

KW - High pressure liquid chromatography

KW - Homovanillic acid

KW - Vanillylmandelic acid

KW - Voltammetry

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U2 - 10.1007/s00706-016-1902-8

DO - 10.1007/s00706-016-1902-8

M3 - Article

AN - SCOPUS:85011650443

VL - 148

SP - 511

EP - 515

JO - Monatshefte fur Chemie

JF - Monatshefte fur Chemie

SN - 0026-9247

IS - 3

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