Voltammetric and amperometric determination of selected catecholamine metabolites using glassy carbon paste electrode

Hana Dejmkova, Hana Adamkova, Jiri Barek, Jiri Zima

Research output: Contribution to journal › Article

Abstract

Abstract: Two methods, using glassy carbon paste electrode for the simultaneous determination homovanillic acid and vanillylmandelic acid, of two catecholamine neurotransmitter metabolites that can serve as biomarkers of several oncological diseases, were developed, based on differential pulse voltammetry and HPLC with amperometric detection. Low selectivity of the voltammetric method was limiting for the determination in urine samples; inclusion of chromatographic separation enabled the application in complex matrix. Graphical abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	511-515
Number of pages	5
Journal	Monatshefte fur Chemie
Volume	148
Issue number	3
DOIs	https://doi.org/10.1007/s00706-016-1902-8
Publication status	Published - 1 Mar 2017
Externally published	Yes

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Keywords

Electrochemistry
High pressure liquid chromatography
Homovanillic acid
Vanillylmandelic acid
Voltammetry

ASJC Scopus subject areas

Chemistry(all)

Cite this

Dejmkova, H., Adamkova, H., Barek, J., & Zima, J. (2017). Voltammetric and amperometric determination of selected catecholamine metabolites using glassy carbon paste electrode. Monatshefte fur Chemie, 148(3), 511-515. https://doi.org/10.1007/s00706-016-1902-8

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AB - Abstract: Two methods, using glassy carbon paste electrode for the simultaneous determination homovanillic acid and vanillylmandelic acid, of two catecholamine neurotransmitter metabolites that can serve as biomarkers of several oncological diseases, were developed, based on differential pulse voltammetry and HPLC with amperometric detection. Low selectivity of the voltammetric method was limiting for the determination in urine samples; inclusion of chromatographic separation enabled the application in complex matrix. Graphical abstract: [Figure not available: see fulltext.]

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Access to Document

10.1007/s00706-016-1902-8