Abstract
A hanging mercury drop electrode and a mercury meniscus modified silver solid amalgam electrode were used as electroanalytical sensors for voltammetric determination of antineoplastic drugs carmustine, lomustine and streptozotocin containing reducible N-nitroso groups. On the example of carmustine it was shown that its one-step reduction proceeds at substantially more negative potentials at amalgam electrode as compared with mercury electrode. Both electrodes offer satisfactory repeatability of current response (relative standard deviations < 5%) using DC voltammetry and differential pulse voltammetry. The achieved limits of determination lie mostly in the 10-7 mol l-1 concentration range. The mentioned voltammetric methods were applied to determination of carmustine and lomustine in pharmaceutical formulations. Further, the mercury meniscus modified silver solid amalgam electrode was employed in a "wall-jet" amperometric detection cell in the determination of carmustine by flow injection analysis. Under optimized conditions (run electrolyte Britton-Robinson buffer of pH 7.0; flow rate 5.5 ml min-1; detection potential-1.5 V; injection volume 0.02 ml) the limit of quantitation 7.1 × 10-6 mol l-1 was achieved.
| Original language | English |
|---|---|
| Pages (from-to) | 1697-1713 |
| Number of pages | 17 |
| Journal | Collection of Czechoslovak Chemical Communications |
| Volume | 74 |
| Issue number | 11-12 |
| DOIs | |
| Publication status | Published - 1 Nov 2009 |
| Externally published | Yes |
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Keywords
- Amperometry
- Carmustine
- Electrochemistry
- Hanging mercury drop electrode
- Lomustine
- Nitroso compounds
- Silver solid amalgam electrode
- Streptozotocin
- Voltammetry
ASJC Scopus subject areas
- Chemistry(all)
Cite this
Voltammetric and amperometric determination of n-nitroso antineoplastic drugs at mercury and amalgam electrodes. / Pecková, Karolina; Vrzalová, Lucie; Bencko, Vladimír; Barek, Jiří.
In: Collection of Czechoslovak Chemical Communications, Vol. 74, No. 11-12, 01.11.2009, p. 1697-1713.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Voltammetric and amperometric determination of n-nitroso antineoplastic drugs at mercury and amalgam electrodes
AU - Pecková, Karolina
AU - Vrzalová, Lucie
AU - Bencko, Vladimír
AU - Barek, Jiří
PY - 2009/11/1
Y1 - 2009/11/1
N2 - A hanging mercury drop electrode and a mercury meniscus modified silver solid amalgam electrode were used as electroanalytical sensors for voltammetric determination of antineoplastic drugs carmustine, lomustine and streptozotocin containing reducible N-nitroso groups. On the example of carmustine it was shown that its one-step reduction proceeds at substantially more negative potentials at amalgam electrode as compared with mercury electrode. Both electrodes offer satisfactory repeatability of current response (relative standard deviations < 5%) using DC voltammetry and differential pulse voltammetry. The achieved limits of determination lie mostly in the 10-7 mol l-1 concentration range. The mentioned voltammetric methods were applied to determination of carmustine and lomustine in pharmaceutical formulations. Further, the mercury meniscus modified silver solid amalgam electrode was employed in a "wall-jet" amperometric detection cell in the determination of carmustine by flow injection analysis. Under optimized conditions (run electrolyte Britton-Robinson buffer of pH 7.0; flow rate 5.5 ml min-1; detection potential-1.5 V; injection volume 0.02 ml) the limit of quantitation 7.1 × 10-6 mol l-1 was achieved.
AB - A hanging mercury drop electrode and a mercury meniscus modified silver solid amalgam electrode were used as electroanalytical sensors for voltammetric determination of antineoplastic drugs carmustine, lomustine and streptozotocin containing reducible N-nitroso groups. On the example of carmustine it was shown that its one-step reduction proceeds at substantially more negative potentials at amalgam electrode as compared with mercury electrode. Both electrodes offer satisfactory repeatability of current response (relative standard deviations < 5%) using DC voltammetry and differential pulse voltammetry. The achieved limits of determination lie mostly in the 10-7 mol l-1 concentration range. The mentioned voltammetric methods were applied to determination of carmustine and lomustine in pharmaceutical formulations. Further, the mercury meniscus modified silver solid amalgam electrode was employed in a "wall-jet" amperometric detection cell in the determination of carmustine by flow injection analysis. Under optimized conditions (run electrolyte Britton-Robinson buffer of pH 7.0; flow rate 5.5 ml min-1; detection potential-1.5 V; injection volume 0.02 ml) the limit of quantitation 7.1 × 10-6 mol l-1 was achieved.
KW - Amperometry
KW - Carmustine
KW - Electrochemistry
KW - Hanging mercury drop electrode
KW - Lomustine
KW - Nitroso compounds
KW - Silver solid amalgam electrode
KW - Streptozotocin
KW - Voltammetry
UR - http://www.scopus.com/inward/record.url?scp=77950633605&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950633605&partnerID=8YFLogxK
U2 - 10.1135/cccc2009112
DO - 10.1135/cccc2009112
M3 - Article
AN - SCOPUS:77950633605
VL - 74
SP - 1697
EP - 1713
JO - Collection of Czechoslovak Chemical Communications
JF - Collection of Czechoslovak Chemical Communications
SN - 0010-0765
IS - 11-12
ER -