Voltammetric and amperometric determination of metoclopramide on boron-doped diamond film electrode

Hana Dejmkova, Candan Dag, Jiri Barek, Jiri Zima

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


New methods for the determination of metoclopramide, antiemetic and gastroprokinetic pharmaceutical, were developed, using differential pulse voltammetry (DPV) and flow injection analysis (FIA) with amperometric detection on a boron-doped diamond film electrode. Electrode pretreatment necessary to ensure the stable results was investigated and it was found, that while DPV requires frequent electrode cleaning, FIA with a sufficiently high flow rate can maintain a stable signal with no signs of electrode passivation. The calculated quantification limits of the DPV and FIA with amperometric detection were 0.13 μmol L -1 and 0.015 μmol L -1, respectively. The applicability of the new methods was verified by the determination of metoclopramide in a pharmaceutical preparation. FIA with amperometic detection proved to be sensitive, accurate and, due to the resistance of the electrode to the passivation, also simple to handle.

Original languageEnglish
Pages (from-to)1310-1317
Number of pages8
JournalCentral European Journal of Chemistry
Issue number4
Publication statusPublished - 1 Aug 2012
Externally publishedYes


  • Boron-doped diamond film electrode
  • Differential pulse voltammetry
  • Flow injection analysis
  • Metoclopramide
  • Passivation

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Voltammetric and amperometric determination of metoclopramide on boron-doped diamond film electrode'. Together they form a unique fingerprint.

Cite this