Voltammetric and amperometric determination of metoclopramide on boron-doped diamond film electrode

Hana Dejmkova, Candan Dag, Jiri Barek, Jiri Zima

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

New methods for the determination of metoclopramide, antiemetic and gastroprokinetic pharmaceutical, were developed, using differential pulse voltammetry (DPV) and flow injection analysis (FIA) with amperometric detection on a boron-doped diamond film electrode. Electrode pretreatment necessary to ensure the stable results was investigated and it was found, that while DPV requires frequent electrode cleaning, FIA with a sufficiently high flow rate can maintain a stable signal with no signs of electrode passivation. The calculated quantification limits of the DPV and FIA with amperometric detection were 0.13 μmol L -1 and 0.015 μmol L -1, respectively. The applicability of the new methods was verified by the determination of metoclopramide in a pharmaceutical preparation. FIA with amperometic detection proved to be sensitive, accurate and, due to the resistance of the electrode to the passivation, also simple to handle.

Original languageEnglish
Pages (from-to)1310-1317
Number of pages8
JournalCentral European Journal of Chemistry
Volume10
Issue number4
DOIs
Publication statusPublished - 1 Aug 2012
Externally publishedYes

Fingerprint

Metoclopramide
Boron
Diamond films
Voltammetry
Electrodes
Passivation
Drug products
Antiemetics
Cleaning
Flow rate
Pharmaceutical Preparations

Keywords

  • Boron-doped diamond film electrode
  • Differential pulse voltammetry
  • Flow injection analysis
  • Metoclopramide
  • Passivation

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

Cite this

Voltammetric and amperometric determination of metoclopramide on boron-doped diamond film electrode. / Dejmkova, Hana; Dag, Candan; Barek, Jiri; Zima, Jiri.

In: Central European Journal of Chemistry, Vol. 10, No. 4, 01.08.2012, p. 1310-1317.

Research output: Contribution to journalArticle

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