Voltammetric and amperometric determination of metoclopramide on boron-doped diamond film electrode

Hana Dejmkova, Candan Dag, Jiri Barek, Jiri Zima

Research output: Contribution to journalArticle

9 Citations (Scopus)


New methods for the determination of metoclopramide, antiemetic and gastroprokinetic pharmaceutical, were developed, using differential pulse voltammetry (DPV) and flow injection analysis (FIA) with amperometric detection on a boron-doped diamond film electrode. Electrode pretreatment necessary to ensure the stable results was investigated and it was found, that while DPV requires frequent electrode cleaning, FIA with a sufficiently high flow rate can maintain a stable signal with no signs of electrode passivation. The calculated quantification limits of the DPV and FIA with amperometric detection were 0.13 μmol L -1 and 0.015 μmol L -1, respectively. The applicability of the new methods was verified by the determination of metoclopramide in a pharmaceutical preparation. FIA with amperometic detection proved to be sensitive, accurate and, due to the resistance of the electrode to the passivation, also simple to handle.

Original languageEnglish
Pages (from-to)1310-1317
Number of pages8
JournalCentral European Journal of Chemistry
Issue number4
Publication statusPublished - 1 Aug 2012
Externally publishedYes


  • Boron-doped diamond film electrode
  • Differential pulse voltammetry
  • Flow injection analysis
  • Metoclopramide
  • Passivation

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

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