Validation of a GC-MS Method for Quantitative Determination of Cyclohexanone by Oxidative Cleavage

E. V. Podrezova, M. S. Lar’kina, M. S. Yusubov, M. V. Belousov, M. K. Zamanova, S. V. Krivoshchekov

Research output: Contribution to journalArticle

Abstract

A GC method for quantitative determination of cyclohexanone by oxidative cleavage was proposed. The research was aimed at the development of a simple, rapid, and effective GC method for quantitative analysis of cyclohexanone in a reaction mixture. Chlorobenzene was used as an internal standard. Qualitative analysis compared mass spectra obtained for each component with mass spectra from the National Institute of Standards and Technology (NIST) database. The method was validated for specificity, linearity, accuracy, robustness, repeatability, and intralaboratory precision.

Original languageEnglish
Pages (from-to)1021-1025
Number of pages5
JournalPharmaceutical Chemistry Journal
Volume52
Issue number12
DOIs
Publication statusPublished - 15 Mar 2019

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Keywords

  • cyclohexanone
  • gas chromatography
  • internal standard
  • oxidative cleavage
  • quantitative determination
  • validation

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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