Use of <sup>199</sup>Tl-diethyldithiocarbanate for radionuclide investigation of the brain: radiochemical and scintigraphic aspects

Abstract

The aim of the work is to define the optimal technological conditions for preparing ¹⁹⁹Tl-DDC injection form extempore and to develop the methodology of single-photon emission computer-aided tomography (SPECT) with this radiopharmaceutical (RP). The lipophilic properties of ¹⁹⁹T1-DDC were tested by ascending paper chromatography in methylethylketone. Sixty-five brain SPECT investigations with ¹⁹⁹T1-DDC were performed. For comparing this method with a known analog, 14 of these patients were examined using ⁹⁹⁴Tc-hezamethyl propylene amine oxime (^99mTc-HMPAO). The injection form of 199Tl-DDC is prepared by heating 9-10 mg of DDC and ¹⁹⁹Tl-chloride solution with specific radioactivity of 2.7-3.6 mCi/ml at 85-90°C in a thermostat for 20 min. The best tomoscintigrams and maximal accumulation of RP in the brain were observed 25-30 min after intravenous injection of ¹⁹⁹T1-DDC. In order to decrease the interference of the Compton effect caused by short-wave electromagnetic radiation of ¹⁹⁹T1, high-power parallel collimator should be used. Preparation of ¹⁹⁹Tl-DDC injection form as described above insures high quality of brain scintigrams.

Original language	English
Pages (from-to)	31-37
Number of pages	7
Journal	Meditsinskaya Radiologiya (Medical Radiology)
Issue number	3
Publication status	Published - May 1998

ASJC Scopus subject areas

Nuclear Energy and Engineering

Fingerprint Dive into the research topics of 'Use of <sup>199</sup>Tl-diethyldithiocarbanate for radionuclide investigation of the brain: radiochemical and scintigraphic aspects'. Together they form a unique fingerprint.

Cite this

@article{ff8dbc35e6bb41e08a59fb8ec8c9327c,

title = "Use of 199Tl-diethyldithiocarbanate for radionuclide investigation of the brain: radiochemical and scintigraphic aspects",

abstract = "The aim of the work is to define the optimal technological conditions for preparing 199Tl-DDC injection form extempore and to develop the methodology of single-photon emission computer-aided tomography (SPECT) with this radiopharmaceutical (RP). The lipophilic properties of 199T1-DDC were tested by ascending paper chromatography in methylethylketone. Sixty-five brain SPECT investigations with 199T1-DDC were performed. For comparing this method with a known analog, 14 of these patients were examined using 994Tc-hezamethyl propylene amine oxime (99mTc-HMPAO). The injection form of 199Tl-DDC is prepared by heating 9-10 mg of DDC and 199Tl-chloride solution with specific radioactivity of 2.7-3.6 mCi/ml at 85-90°C in a thermostat for 20 min. The best tomoscintigrams and maximal accumulation of RP in the brain were observed 25-30 min after intravenous injection of 199T1-DDC. In order to decrease the interference of the Compton effect caused by short-wave electromagnetic radiation of 199T1, high-power parallel collimator should be used. Preparation of 199Tl-DDC injection form as described above insures high quality of brain scintigrams.",

author = "Lishmanov, {Yu B.} and Dygai, {I. A.} and Skuridin, {V. S.} and Shvera, {I. Yu} and Krivonogov, {N. G.}",

year = "1998",

month = may,

language = "English",

pages = "31--37",

journal = "Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'",

issn = "0025-8334",

publisher = "Izdatel'sto Radekon",

number = "3",

}

TY - JOUR

T1 - Use of 199Tl-diethyldithiocarbanate for radionuclide investigation of the brain

T2 - radiochemical and scintigraphic aspects

AU - Lishmanov, Yu B.

AU - Dygai, I. A.

AU - Skuridin, V. S.

AU - Shvera, I. Yu

AU - Krivonogov, N. G.

PY - 1998/5

Y1 - 1998/5

N2 - The aim of the work is to define the optimal technological conditions for preparing 199Tl-DDC injection form extempore and to develop the methodology of single-photon emission computer-aided tomography (SPECT) with this radiopharmaceutical (RP). The lipophilic properties of 199T1-DDC were tested by ascending paper chromatography in methylethylketone. Sixty-five brain SPECT investigations with 199T1-DDC were performed. For comparing this method with a known analog, 14 of these patients were examined using 994Tc-hezamethyl propylene amine oxime (99mTc-HMPAO). The injection form of 199Tl-DDC is prepared by heating 9-10 mg of DDC and 199Tl-chloride solution with specific radioactivity of 2.7-3.6 mCi/ml at 85-90°C in a thermostat for 20 min. The best tomoscintigrams and maximal accumulation of RP in the brain were observed 25-30 min after intravenous injection of 199T1-DDC. In order to decrease the interference of the Compton effect caused by short-wave electromagnetic radiation of 199T1, high-power parallel collimator should be used. Preparation of 199Tl-DDC injection form as described above insures high quality of brain scintigrams.

AB - The aim of the work is to define the optimal technological conditions for preparing 199Tl-DDC injection form extempore and to develop the methodology of single-photon emission computer-aided tomography (SPECT) with this radiopharmaceutical (RP). The lipophilic properties of 199T1-DDC were tested by ascending paper chromatography in methylethylketone. Sixty-five brain SPECT investigations with 199T1-DDC were performed. For comparing this method with a known analog, 14 of these patients were examined using 994Tc-hezamethyl propylene amine oxime (99mTc-HMPAO). The injection form of 199Tl-DDC is prepared by heating 9-10 mg of DDC and 199Tl-chloride solution with specific radioactivity of 2.7-3.6 mCi/ml at 85-90°C in a thermostat for 20 min. The best tomoscintigrams and maximal accumulation of RP in the brain were observed 25-30 min after intravenous injection of 199T1-DDC. In order to decrease the interference of the Compton effect caused by short-wave electromagnetic radiation of 199T1, high-power parallel collimator should be used. Preparation of 199Tl-DDC injection form as described above insures high quality of brain scintigrams.

UR - http://www.scopus.com/inward/record.url?scp=0032068024&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032068024&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032068024

SP - 31

EP - 37

JO - Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'

JF - Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'

SN - 0025-8334

IS - 3

ER -

Use of ¹⁹⁹Tl-diethyldithiocarbanate for radionuclide investigation of the brain: radiochemical and scintigraphic aspects

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint Dive into the research topics of 'Use of <sup>199</sup>Tl-diethyldithiocarbanate for radionuclide investigation of the brain: radiochemical and scintigraphic aspects'. Together they form a unique fingerprint.

Cite this