Abstract
The aim of the work is to define the optimal technological conditions for preparing 199Tl-DDC injection form extempore and to develop the methodology of single-photon emission computer-aided tomography (SPECT) with this radiopharmaceutical (RP). The lipophilic properties of 199T1-DDC were tested by ascending paper chromatography in methylethylketone. Sixty-five brain SPECT investigations with 199T1-DDC were performed. For comparing this method with a known analog, 14 of these patients were examined using 994Tc-hezamethyl propylene amine oxime (99mTc-HMPAO). The injection form of 199Tl-DDC is prepared by heating 9-10 mg of DDC and 199Tl-chloride solution with specific radioactivity of 2.7-3.6 mCi/ml at 85-90°C in a thermostat for 20 min. The best tomoscintigrams and maximal accumulation of RP in the brain were observed 25-30 min after intravenous injection of 199T1-DDC. In order to decrease the interference of the Compton effect caused by short-wave electromagnetic radiation of 199T1, high-power parallel collimator should be used. Preparation of 199Tl-DDC injection form as described above insures high quality of brain scintigrams.
| Original language | English |
|---|---|
| Pages (from-to) | 31-37 |
| Number of pages | 7 |
| Journal | Meditsinskaya Radiologiya (Medical Radiology) |
| Issue number | 3 |
| Publication status | Published - May 1998 |
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ASJC Scopus subject areas
- Nuclear Energy and Engineering
Cite this
Use of 199Tl-diethyldithiocarbanate for radionuclide investigation of the brain : radiochemical and scintigraphic aspects. / Lishmanov, Yu B.; Dygai, I. A.; Skuridin, V. S.; Shvera, I. Yu; Krivonogov, N. G.
In: Meditsinskaya Radiologiya (Medical Radiology), No. 3, 05.1998, p. 31-37.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Use of 199Tl-diethyldithiocarbanate for radionuclide investigation of the brain
T2 - radiochemical and scintigraphic aspects
AU - Lishmanov, Yu B.
AU - Dygai, I. A.
AU - Skuridin, V. S.
AU - Shvera, I. Yu
AU - Krivonogov, N. G.
PY - 1998/5
Y1 - 1998/5
N2 - The aim of the work is to define the optimal technological conditions for preparing 199Tl-DDC injection form extempore and to develop the methodology of single-photon emission computer-aided tomography (SPECT) with this radiopharmaceutical (RP). The lipophilic properties of 199T1-DDC were tested by ascending paper chromatography in methylethylketone. Sixty-five brain SPECT investigations with 199T1-DDC were performed. For comparing this method with a known analog, 14 of these patients were examined using 994Tc-hezamethyl propylene amine oxime (99mTc-HMPAO). The injection form of 199Tl-DDC is prepared by heating 9-10 mg of DDC and 199Tl-chloride solution with specific radioactivity of 2.7-3.6 mCi/ml at 85-90°C in a thermostat for 20 min. The best tomoscintigrams and maximal accumulation of RP in the brain were observed 25-30 min after intravenous injection of 199T1-DDC. In order to decrease the interference of the Compton effect caused by short-wave electromagnetic radiation of 199T1, high-power parallel collimator should be used. Preparation of 199Tl-DDC injection form as described above insures high quality of brain scintigrams.
AB - The aim of the work is to define the optimal technological conditions for preparing 199Tl-DDC injection form extempore and to develop the methodology of single-photon emission computer-aided tomography (SPECT) with this radiopharmaceutical (RP). The lipophilic properties of 199T1-DDC were tested by ascending paper chromatography in methylethylketone. Sixty-five brain SPECT investigations with 199T1-DDC were performed. For comparing this method with a known analog, 14 of these patients were examined using 994Tc-hezamethyl propylene amine oxime (99mTc-HMPAO). The injection form of 199Tl-DDC is prepared by heating 9-10 mg of DDC and 199Tl-chloride solution with specific radioactivity of 2.7-3.6 mCi/ml at 85-90°C in a thermostat for 20 min. The best tomoscintigrams and maximal accumulation of RP in the brain were observed 25-30 min after intravenous injection of 199T1-DDC. In order to decrease the interference of the Compton effect caused by short-wave electromagnetic radiation of 199T1, high-power parallel collimator should be used. Preparation of 199Tl-DDC injection form as described above insures high quality of brain scintigrams.
UR - http://www.scopus.com/inward/record.url?scp=0032068024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032068024&partnerID=8YFLogxK
M3 - Article
SP - 31
EP - 37
JO - Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
JF - Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
SN - 0025-8334
IS - 3
ER -