Use of 199Tl-diethyldithiocarbanate for radionuclide investigation of the brain: radiochemical and scintigraphic aspects

Yu B. Lishmanov, I. A. Dygai, V. S. Skuridin, I. Yu Shvera, N. G. Krivonogov

Research output: Contribution to journalArticle

Abstract

The aim of the work is to define the optimal technological conditions for preparing 199Tl-DDC injection form extempore and to develop the methodology of single-photon emission computer-aided tomography (SPECT) with this radiopharmaceutical (RP). The lipophilic properties of 199T1-DDC were tested by ascending paper chromatography in methylethylketone. Sixty-five brain SPECT investigations with 199T1-DDC were performed. For comparing this method with a known analog, 14 of these patients were examined using 994Tc-hezamethyl propylene amine oxime (99mTc-HMPAO). The injection form of 199Tl-DDC is prepared by heating 9-10 mg of DDC and 199Tl-chloride solution with specific radioactivity of 2.7-3.6 mCi/ml at 85-90°C in a thermostat for 20 min. The best tomoscintigrams and maximal accumulation of RP in the brain were observed 25-30 min after intravenous injection of 199T1-DDC. In order to decrease the interference of the Compton effect caused by short-wave electromagnetic radiation of 199T1, high-power parallel collimator should be used. Preparation of 199Tl-DDC injection form as described above insures high quality of brain scintigrams.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalMeditsinskaya Radiologiya (Medical Radiology)
Issue number3
Publication statusPublished - May 1998

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ASJC Scopus subject areas

  • Nuclear Energy and Engineering

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