Abstract
In the presented work the simultaneous use of ultrasound in tracking and smart release was investigated. Hybrid microparticles based on an iron core coated by a polysaccharide were prepared and loaded with doxorubicin. The possibility to trigger and control the release of the payload was demonstrated by application of ultrasound cycles at different power and time length. Results clearly indicate a direct correlation between the intensity of the release with the two parameters. A preliminary test using Sus Domestic liver demonstrates the possibility to visualize the faith of the microparticles after injection at the target site by a linear array ultrasound transducer. The dual function of the ultrasound; to visualize the position of the microparticles and afterwards trigger the release by changing the frequency was demonstrated offering a great perspective for a future biomedical application.
| Original language | English |
|---|---|
| Title of host publication | NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application |
| Publisher | TANGER Ltd. |
| Pages | 485-488 |
| Number of pages | 4 |
| ISBN (Electronic) | 9788087294819 |
| Publication status | Published - 1 Jan 2018 |
| Event | 9th International Conference on Nanomaterials - Research and Application, NANOCON 2017 - Brno, Czech Republic Duration: 18 Oct 2017 → 20 Oct 2017 |
Publication series
| Name | NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application |
|---|---|
| Volume | 2017-October |
Conference
| Conference | 9th International Conference on Nanomaterials - Research and Application, NANOCON 2017 |
|---|---|
| Country | Czech Republic |
| City | Brno |
| Period | 18.10.17 → 20.10.17 |
Fingerprint
Keywords
- Doxorubicin
- Iron oxide
- Microparticles
- Stimuli-responsive release
- Ultrasound
ASJC Scopus subject areas
- Biotechnology
- Electrical and Electronic Engineering
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
Cite this
Ultrasound irradiation to visualize and trigger the release of doxorubicin from hybrid microparticles. / Postnikov, S. Pavel; Di Martino, Antonio; Vlasov, S. Sergei; Kurtukov, V. Viktor; Sedlarik, Vladimir.
NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application. TANGER Ltd., 2018. p. 485-488 (NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application; Vol. 2017-October).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Ultrasound irradiation to visualize and trigger the release of doxorubicin from hybrid microparticles
AU - Postnikov, S. Pavel
AU - Di Martino, Antonio
AU - Vlasov, S. Sergei
AU - Kurtukov, V. Viktor
AU - Sedlarik, Vladimir
PY - 2018/1/1
Y1 - 2018/1/1
N2 - In the presented work the simultaneous use of ultrasound in tracking and smart release was investigated. Hybrid microparticles based on an iron core coated by a polysaccharide were prepared and loaded with doxorubicin. The possibility to trigger and control the release of the payload was demonstrated by application of ultrasound cycles at different power and time length. Results clearly indicate a direct correlation between the intensity of the release with the two parameters. A preliminary test using Sus Domestic liver demonstrates the possibility to visualize the faith of the microparticles after injection at the target site by a linear array ultrasound transducer. The dual function of the ultrasound; to visualize the position of the microparticles and afterwards trigger the release by changing the frequency was demonstrated offering a great perspective for a future biomedical application.
AB - In the presented work the simultaneous use of ultrasound in tracking and smart release was investigated. Hybrid microparticles based on an iron core coated by a polysaccharide were prepared and loaded with doxorubicin. The possibility to trigger and control the release of the payload was demonstrated by application of ultrasound cycles at different power and time length. Results clearly indicate a direct correlation between the intensity of the release with the two parameters. A preliminary test using Sus Domestic liver demonstrates the possibility to visualize the faith of the microparticles after injection at the target site by a linear array ultrasound transducer. The dual function of the ultrasound; to visualize the position of the microparticles and afterwards trigger the release by changing the frequency was demonstrated offering a great perspective for a future biomedical application.
KW - Doxorubicin
KW - Iron oxide
KW - Microparticles
KW - Stimuli-responsive release
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85051844386&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051844386&partnerID=8YFLogxK
M3 - Conference contribution
T3 - NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application
SP - 485
EP - 488
BT - NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application
PB - TANGER Ltd.
ER -