Ultrasound irradiation to visualize and trigger the release of doxorubicin from hybrid microparticles

S. Pavel Postnikov, Antonio Di Martino, S. Sergei Vlasov, V. Viktor Kurtukov, Vladimir Sedlarik

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the presented work the simultaneous use of ultrasound in tracking and smart release was investigated. Hybrid microparticles based on an iron core coated by a polysaccharide were prepared and loaded with doxorubicin. The possibility to trigger and control the release of the payload was demonstrated by application of ultrasound cycles at different power and time length. Results clearly indicate a direct correlation between the intensity of the release with the two parameters. A preliminary test using Sus Domestic liver demonstrates the possibility to visualize the faith of the microparticles after injection at the target site by a linear array ultrasound transducer. The dual function of the ultrasound; to visualize the position of the microparticles and afterwards trigger the release by changing the frequency was demonstrated offering a great perspective for a future biomedical application.

Original languageEnglish
Title of host publicationNANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application
PublisherTANGER Ltd.
Pages485-488
Number of pages4
ISBN (Electronic)9788087294819
Publication statusPublished - 1 Jan 2018
Event9th International Conference on Nanomaterials - Research and Application, NANOCON 2017 - Brno, Czech Republic
Duration: 18 Oct 201720 Oct 2017

Publication series

NameNANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application
Volume2017-October

Conference

Conference9th International Conference on Nanomaterials - Research and Application, NANOCON 2017
CountryCzech Republic
CityBrno
Period18.10.1720.10.17

Fingerprint

Transducers
Doxorubicin
Polysaccharides
Iron
Ultrasonics
Irradiation
Injections
Liver

Keywords

  • Doxorubicin
  • Iron oxide
  • Microparticles
  • Stimuli-responsive release
  • Ultrasound

ASJC Scopus subject areas

  • Biotechnology
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites

Cite this

Postnikov, S. P., Di Martino, A., Vlasov, S. S., Kurtukov, V. V., & Sedlarik, V. (2018). Ultrasound irradiation to visualize and trigger the release of doxorubicin from hybrid microparticles. In NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application (pp. 485-488). (NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application; Vol. 2017-October). TANGER Ltd..

Ultrasound irradiation to visualize and trigger the release of doxorubicin from hybrid microparticles. / Postnikov, S. Pavel; Di Martino, Antonio; Vlasov, S. Sergei; Kurtukov, V. Viktor; Sedlarik, Vladimir.

NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application. TANGER Ltd., 2018. p. 485-488 (NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application; Vol. 2017-October).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Postnikov, SP, Di Martino, A, Vlasov, SS, Kurtukov, VV & Sedlarik, V 2018, Ultrasound irradiation to visualize and trigger the release of doxorubicin from hybrid microparticles. in NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application. NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application, vol. 2017-October, TANGER Ltd., pp. 485-488, 9th International Conference on Nanomaterials - Research and Application, NANOCON 2017, Brno, Czech Republic, 18.10.17.
Postnikov SP, Di Martino A, Vlasov SS, Kurtukov VV, Sedlarik V. Ultrasound irradiation to visualize and trigger the release of doxorubicin from hybrid microparticles. In NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application. TANGER Ltd. 2018. p. 485-488. (NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application).
Postnikov, S. Pavel ; Di Martino, Antonio ; Vlasov, S. Sergei ; Kurtukov, V. Viktor ; Sedlarik, Vladimir. / Ultrasound irradiation to visualize and trigger the release of doxorubicin from hybrid microparticles. NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application. TANGER Ltd., 2018. pp. 485-488 (NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application).
@inproceedings{32603f45cc9742dda6da6ac0bf99b53e,
title = "Ultrasound irradiation to visualize and trigger the release of doxorubicin from hybrid microparticles",
abstract = "In the presented work the simultaneous use of ultrasound in tracking and smart release was investigated. Hybrid microparticles based on an iron core coated by a polysaccharide were prepared and loaded with doxorubicin. The possibility to trigger and control the release of the payload was demonstrated by application of ultrasound cycles at different power and time length. Results clearly indicate a direct correlation between the intensity of the release with the two parameters. A preliminary test using Sus Domestic liver demonstrates the possibility to visualize the faith of the microparticles after injection at the target site by a linear array ultrasound transducer. The dual function of the ultrasound; to visualize the position of the microparticles and afterwards trigger the release by changing the frequency was demonstrated offering a great perspective for a future biomedical application.",
keywords = "Doxorubicin, Iron oxide, Microparticles, Stimuli-responsive release, Ultrasound",
author = "Postnikov, {S. Pavel} and {Di Martino}, Antonio and Vlasov, {S. Sergei} and Kurtukov, {V. Viktor} and Vladimir Sedlarik",
year = "2018",
month = "1",
day = "1",
language = "English",
series = "NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application",
publisher = "TANGER Ltd.",
pages = "485--488",
booktitle = "NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application",

}

TY - GEN

T1 - Ultrasound irradiation to visualize and trigger the release of doxorubicin from hybrid microparticles

AU - Postnikov, S. Pavel

AU - Di Martino, Antonio

AU - Vlasov, S. Sergei

AU - Kurtukov, V. Viktor

AU - Sedlarik, Vladimir

PY - 2018/1/1

Y1 - 2018/1/1

N2 - In the presented work the simultaneous use of ultrasound in tracking and smart release was investigated. Hybrid microparticles based on an iron core coated by a polysaccharide were prepared and loaded with doxorubicin. The possibility to trigger and control the release of the payload was demonstrated by application of ultrasound cycles at different power and time length. Results clearly indicate a direct correlation between the intensity of the release with the two parameters. A preliminary test using Sus Domestic liver demonstrates the possibility to visualize the faith of the microparticles after injection at the target site by a linear array ultrasound transducer. The dual function of the ultrasound; to visualize the position of the microparticles and afterwards trigger the release by changing the frequency was demonstrated offering a great perspective for a future biomedical application.

AB - In the presented work the simultaneous use of ultrasound in tracking and smart release was investigated. Hybrid microparticles based on an iron core coated by a polysaccharide were prepared and loaded with doxorubicin. The possibility to trigger and control the release of the payload was demonstrated by application of ultrasound cycles at different power and time length. Results clearly indicate a direct correlation between the intensity of the release with the two parameters. A preliminary test using Sus Domestic liver demonstrates the possibility to visualize the faith of the microparticles after injection at the target site by a linear array ultrasound transducer. The dual function of the ultrasound; to visualize the position of the microparticles and afterwards trigger the release by changing the frequency was demonstrated offering a great perspective for a future biomedical application.

KW - Doxorubicin

KW - Iron oxide

KW - Microparticles

KW - Stimuli-responsive release

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=85051844386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051844386&partnerID=8YFLogxK

M3 - Conference contribution

T3 - NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application

SP - 485

EP - 488

BT - NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application

PB - TANGER Ltd.

ER -