Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles

Sen W. Kwok, Joseph R. Fotsing, Rebecca J. Fraser, Valentin O. Rodionov, Valery V. Fokin

Research output: Contribution to journalArticle

184 Citations (Scopus)

Abstract

Figure Presented. 1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and moisture.

Original languageEnglish
Pages (from-to)4217-4219
Number of pages3
JournalOrganic Letters
Volume12
Issue number19
DOIs
Publication statusPublished - 1 Oct 2010
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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  • Cite this

    Kwok, S. W., Fotsing, J. R., Fraser, R. J., Rodionov, V. O., & Fokin, V. V. (2010). Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles. Organic Letters, 12(19), 4217-4219. https://doi.org/10.1021/ol101568d