Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles

Sen W. Kwok, Joseph R. Fotsing, Rebecca J. Fraser, Valentin O. Rodionov, Valery V. Fokin

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

Figure Presented. 1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and moisture.

Original languageEnglish
Pages (from-to)4217-4219
Number of pages3
JournalOrganic Letters
Volume12
Issue number19
DOIs
Publication statusPublished - 1 Oct 2010
Externally publishedYes

Fingerprint

Triazoles
Alkynes
Azides
alkynes
Dimethyl Sulfoxide
moisture
hydroxides
Transition metals
Moisture
Metals
transition metals
Oxygen
catalysts
Catalysts
oxygen
synthesis
hydroxide ion

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Kwok, S. W., Fotsing, J. R., Fraser, R. J., Rodionov, V. O., & Fokin, V. V. (2010). Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles. Organic Letters, 12(19), 4217-4219. https://doi.org/10.1021/ol101568d

Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles. / Kwok, Sen W.; Fotsing, Joseph R.; Fraser, Rebecca J.; Rodionov, Valentin O.; Fokin, Valery V.

In: Organic Letters, Vol. 12, No. 19, 01.10.2010, p. 4217-4219.

Research output: Contribution to journalArticle

Kwok, SW, Fotsing, JR, Fraser, RJ, Rodionov, VO & Fokin, VV 2010, 'Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles', Organic Letters, vol. 12, no. 19, pp. 4217-4219. https://doi.org/10.1021/ol101568d
Kwok SW, Fotsing JR, Fraser RJ, Rodionov VO, Fokin VV. Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles. Organic Letters. 2010 Oct 1;12(19):4217-4219. https://doi.org/10.1021/ol101568d
Kwok, Sen W. ; Fotsing, Joseph R. ; Fraser, Rebecca J. ; Rodionov, Valentin O. ; Fokin, Valery V. / Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles. In: Organic Letters. 2010 ; Vol. 12, No. 19. pp. 4217-4219.
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