Trace elements and nanoparticles: Certain approaches to cancer targeted diagnostics and therapy

Igor A. Khlusov, Galina B. Slepchenko, Georgy T. Dambaev, Leonid V. Zagrebin, Sergey S. Shestov, Sergey A. Antipov, Taisia A. Feduschak, Marina Yu Khlusova, Oleg V. Kokorev, Anatoly Ye Yermakov, Mikhail A. Uymin, Anna M. Nekrasova

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Dissatisfaction with results of combined (surgery, chemotherapy, irradiation) cancer treatment determines relevance and availability of search new trends, such as development of immuno(bio)therapy methods. However, high theoretical and experimental antitumor potential of cancer immuno(bio)therapy haven’t found its clinical confirmation yet. One of basic reasons of unsatisfactory treatment results and poor forecast is considered as late disease diagnostics. Nanomedicine seems to be a way out of this situation. On the one hand, new scientific field is aimed at development of material and technical base of diagnostics and treatment of diseases. Analysis of nanomedicine publications showed that electrochemical methods were one of its leading analytical tools. On the other hand, address delivery (including ferreed delivery) of drugs and biological molecules into tumor tissue serves as its the most important therapeutic approach. At the same time, proper value of trace elements and nanoparticles in organism vital activity, diagnostics and therapy of cancer has not yet been sufficiently studied. In this connection, this chapter is devoted to: 1) our efforts to develop method of trace elements voltammeter control in biological substances for targeted cancer diagnostics; 2) finding out a role of trace elements imbalance in oncological patients and human tumor cell lines as a base of elaboration of approaches to cancer targeted diagnostics and therapy; 3) proper results of targeted magnetocontrollable delivery of cytostatic and nanoparticle composites into tumor cells and tissues.

Original languageEnglish
Title of host publicationNeuro-Oncology and Cancer Targeted Therapy
PublisherNova Science Publishers, Inc.
Pages1-64
Number of pages64
ISBN (Electronic)9781536113556
ISBN (Print)9781616687083
Publication statusPublished - 1 Jan 2010

ASJC Scopus subject areas

  • Medicine(all)

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