Toxicological characterization of cumazid

M. V. Belousov, T. P. Novozheeva, R. R. Akhmedzhanov, L. N. Novitskaya, M. S. Yusubov, D. L. Aminin, S. A. Avilov, V. A. Stonik, V. I. Kalinin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cumazid, a new prophylactic immunotherapy preparation, has been created based on the total glycoside fraction isolated from Cucumaria japonica sea cucumber species. The acute and chronic toxicity of the preparation has been characterized according to the pharmacopoeieal requirements. With respect to the acute toxicity upon intragastric administration, cumazid belongs to class IV (weakly dangerous) drugs. In 3-month chronic tests, cumazid administered in doses wit-hin 1 - 100 μg/kg did not produce any significant toxic action on laboratory animals.

Original languageEnglish
Pages (from-to)22-24
Number of pages3
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume73
Issue number2
Publication statusPublished - 2010

Fingerprint

Toxicology
Toxicity
Cucumaria
Sea Cucumbers
Toxic Actions
Wit and Humor
Laboratory Animals
Glycosides
Immunotherapy
Animals
Pharmaceutical Preparations
cumazid

Keywords

  • Acute toxicity
  • Chronic toxicity
  • Cucumaria japonica
  • Cumazid
  • Triterpene glycosides

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Belousov, M. V., Novozheeva, T. P., Akhmedzhanov, R. R., Novitskaya, L. N., Yusubov, M. S., Aminin, D. L., ... Kalinin, V. I. (2010). Toxicological characterization of cumazid. Eksperimental'naya i Klinicheskaya Farmakologiya, 73(2), 22-24.

Toxicological characterization of cumazid. / Belousov, M. V.; Novozheeva, T. P.; Akhmedzhanov, R. R.; Novitskaya, L. N.; Yusubov, M. S.; Aminin, D. L.; Avilov, S. A.; Stonik, V. A.; Kalinin, V. I.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 73, No. 2, 2010, p. 22-24.

Research output: Contribution to journalArticle

Belousov, MV, Novozheeva, TP, Akhmedzhanov, RR, Novitskaya, LN, Yusubov, MS, Aminin, DL, Avilov, SA, Stonik, VA & Kalinin, VI 2010, 'Toxicological characterization of cumazid', Eksperimental'naya i Klinicheskaya Farmakologiya, vol. 73, no. 2, pp. 22-24.
Belousov, M. V. ; Novozheeva, T. P. ; Akhmedzhanov, R. R. ; Novitskaya, L. N. ; Yusubov, M. S. ; Aminin, D. L. ; Avilov, S. A. ; Stonik, V. A. ; Kalinin, V. I. / Toxicological characterization of cumazid. In: Eksperimental'naya i Klinicheskaya Farmakologiya. 2010 ; Vol. 73, No. 2. pp. 22-24.
@article{dd86c7ce07be43be91f6691c8106055f,
title = "Toxicological characterization of cumazid",
abstract = "Cumazid, a new prophylactic immunotherapy preparation, has been created based on the total glycoside fraction isolated from Cucumaria japonica sea cucumber species. The acute and chronic toxicity of the preparation has been characterized according to the pharmacopoeieal requirements. With respect to the acute toxicity upon intragastric administration, cumazid belongs to class IV (weakly dangerous) drugs. In 3-month chronic tests, cumazid administered in doses wit-hin 1 - 100 μg/kg did not produce any significant toxic action on laboratory animals.",
keywords = "Acute toxicity, Chronic toxicity, Cucumaria japonica, Cumazid, Triterpene glycosides",
author = "Belousov, {M. V.} and Novozheeva, {T. P.} and Akhmedzhanov, {R. R.} and Novitskaya, {L. N.} and Yusubov, {M. S.} and Aminin, {D. L.} and Avilov, {S. A.} and Stonik, {V. A.} and Kalinin, {V. I.}",
year = "2010",
language = "English",
volume = "73",
pages = "22--24",
journal = "Eksperimental'naya i Klinicheskaya Farmakologiya",
issn = "0869-2092",
publisher = "Izdatelstvo Meditsina",
number = "2",

}

TY - JOUR

T1 - Toxicological characterization of cumazid

AU - Belousov, M. V.

AU - Novozheeva, T. P.

AU - Akhmedzhanov, R. R.

AU - Novitskaya, L. N.

AU - Yusubov, M. S.

AU - Aminin, D. L.

AU - Avilov, S. A.

AU - Stonik, V. A.

AU - Kalinin, V. I.

PY - 2010

Y1 - 2010

N2 - Cumazid, a new prophylactic immunotherapy preparation, has been created based on the total glycoside fraction isolated from Cucumaria japonica sea cucumber species. The acute and chronic toxicity of the preparation has been characterized according to the pharmacopoeieal requirements. With respect to the acute toxicity upon intragastric administration, cumazid belongs to class IV (weakly dangerous) drugs. In 3-month chronic tests, cumazid administered in doses wit-hin 1 - 100 μg/kg did not produce any significant toxic action on laboratory animals.

AB - Cumazid, a new prophylactic immunotherapy preparation, has been created based on the total glycoside fraction isolated from Cucumaria japonica sea cucumber species. The acute and chronic toxicity of the preparation has been characterized according to the pharmacopoeieal requirements. With respect to the acute toxicity upon intragastric administration, cumazid belongs to class IV (weakly dangerous) drugs. In 3-month chronic tests, cumazid administered in doses wit-hin 1 - 100 μg/kg did not produce any significant toxic action on laboratory animals.

KW - Acute toxicity

KW - Chronic toxicity

KW - Cucumaria japonica

KW - Cumazid

KW - Triterpene glycosides

UR - http://www.scopus.com/inward/record.url?scp=77950259375&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950259375&partnerID=8YFLogxK

M3 - Article

VL - 73

SP - 22

EP - 24

JO - Eksperimental'naya i Klinicheskaya Farmakologiya

JF - Eksperimental'naya i Klinicheskaya Farmakologiya

SN - 0869-2092

IS - 2

ER -