Toxicological characterization of cumazid

M. V. Belousov, T. P. Novozheeva, R. R. Akhmedzhanov, L. N. Novitskaya, M. S. Yusubov, D. L. Aminin, S. A. Avilov, V. A. Stonik, V. I. Kalinin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cumazid, a new prophylactic immunotherapy preparation, has been created based on the total glycoside fraction isolated from Cucumaria japonica sea cucumber species. The acute and chronic toxicity of the preparation has been characterized according to the pharmacopoeieal requirements. With respect to the acute toxicity upon intragastric administration, cumazid belongs to class IV (weakly dangerous) drugs. In 3-month chronic tests, cumazid administered in doses wit-hin 1 - 100 μg/kg did not produce any significant toxic action on laboratory animals.

Original languageEnglish
Pages (from-to)22-24
Number of pages3
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume73
Issue number2
Publication statusPublished - 2010

Keywords

  • Acute toxicity
  • Chronic toxicity
  • Cucumaria japonica
  • Cumazid
  • Triterpene glycosides

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Fingerprint Dive into the research topics of 'Toxicological characterization of cumazid'. Together they form a unique fingerprint.

  • Cite this

    Belousov, M. V., Novozheeva, T. P., Akhmedzhanov, R. R., Novitskaya, L. N., Yusubov, M. S., Aminin, D. L., Avilov, S. A., Stonik, V. A., & Kalinin, V. I. (2010). Toxicological characterization of cumazid. Eksperimental'naya i Klinicheskaya Farmakologiya, 73(2), 22-24.